Notch signaling plays a key role in the development of pancreatic cancer. Among the four identified Notch receptors, Notch1 and Notch2 share the highest homology. Notch1 has been reported to be an oncogene but some reports indicate that Notch2, not Notch1, plays a key role in pancreatic carcinogenesis. As both are transcription factors, examination of their genomic binding sites might reveal in...

Story in Brief Corn steep liquor (CSL) and fermented ammoniated condensed whey (FACW) were compared to cottonseed meal (CS1\I) as protein sources f())' wintering 6 I lactating first-calf Hereford heifers and 32 yearling HerefOl'd heifers on nati\'e range. Cattle were allotted by weight and individually fed 6 days per week fill' 12 weeks one of four protein treatments: negative control (I\C). po...

Much attention has been given in recent years to observations and models that show that variations in the transport of the Atlantic Meridional Overturning Circulation (AMOC) and in the Gulf Stream (GS) can contribute to interannual, decadal, and multi-decadal variations in coastal sea level (CSL) along the US East Coast. However, less is known about the impact of short-term (time scales of days...

We study the relationship between Concurrent Separation Logic (CSL) and the assume-guarantee (A-G) method (a.k.a. rely-guarantee method). We show in three steps that CSL can be treated as a specialization of the A-G method for well-synchronized concurrent programs. First, we present an A-G based program logic for a low-level language with built-in locking primitives. Then we extend the program ...

The Continuous Stochastic Logic (CSL) is a powerful means to state properties which refer to Continuous Time Markov Chains (CTMCs). The verification of such properties on a model can be achieved through a suitable algorithm. In this doctoral thesis, the CSL logic has been considered and two major aspects have been addressed: the analysis of its expressiveness and the study of methods for a deco...

Notch is a conserved signaling pathway that specifies cell fates in metazoans. Receptor-ligand interactions induce changes in gene expression, which is regulated by the transcription factor CBF1/Su(H)/Lag-1 (CSL). CSL interacts with coregulators to repress and activate transcription from Notch target genes. While the molecular details of the activator complex are relatively well understood, the...

BACKGROUND Cbf11 and Cbf12, the fission yeast CSL transcription factors, have been implicated in the regulation of cell-cycle progression, but no specific roles have been described and their target genes have been only partially mapped. METHODOLOGY/PRINCIPAL FINDINGS Using a combination of transcriptome profiling under various conditions and genome-wide analysis of CSL-DNA interactions, we id...

We argue that Chinese Sign Language (CSL) provides new insights into temporal anaphora, as well puzzles. Partee 1973 showed talk in English involves abstract anaphoric mechanisms akin to pronouns, although with a very different form. Schlenker 2013 argued American (ASL), one and the same overt pronominal form, pointing sign, can have individual uses, but his data involved loci across domains: n...

background & aim: medicinal plants is very potential to be used as a supplementary feed as well as feed additive in broilers.this experiment was conducted to investigate the effects of milk thistle (mt) and thyme seeds (ts) on the performance in broilers. experimental: in this study, 160 one-day-old (ross 308) male broiler chicks were divided randomly into four major groups with 4 replicate...