background: polycystic ovary syndrome (pcos) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology. objective: we examined the possible association of adiponectin and insulin receptor gene polymorphisms with pcos. materials and methods: a total of 186 women with pcos using...

Severe acute respiratory syndrome coronavirus has a great role in causing illness humans and the most important relationship of its spike proteins with host ACE-2 receptors. After entry into human body, viral S protein receptor-binding domain binds to receptor. Two modes explained this paper an shedding. The shedding induces process cells by binding SARS-CoV-2 proteins. residues arginine lysine...

Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...

Objective(s): Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to the non-classical and classical oestrogen receptors, respectively, the present study was aimed to observe the osteoprotective effect of phytoestrogens on BPA-induced osteoblasts in hFOB 1.19 cells.Materials and Methods:...

the affinity of low density lipoprotein (ldl) to its receptor is very important, because most of ldl-uptake pathway is done by the ldl receptor and the change in size of ldl particle and the modification in its components may affects the ldl affinity for its receptor. in this study, the effects of lipophilic agents such as vitamin e and seven volatile oils: anethol, eugenol, geraniol, limonene,...

Background &Objectives;: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. Methods: The study ...

in this study using clonidine (a mixed ?2 /i1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (i1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. morphine-dependence was induced by administration of increasing doses of morphine in mice. after the last administration of ...

Introduction: 5-HT1A receptor is related with a variety of neuropsychiatric disorders. . In this study a phenolic analogue derived from DWAY [Desmethyl WAY-100635 (N-(2-(1-(4-(2-methoxyphenyl)piperazinyl)-ethyl))-N-(2-pyridinyl) cyclohexanecarboxamide)] is used to design the desired structure of 5-HT1A receptor imaging agents after labeling with [99mTc (CO) 3(H2O) 3] + cor...

The human body defends itself against foreign invaders such as bacteria and viruses by a defense system that involves antibodies and thymus-derived lymphocytes (T cells). A major advance over the past decade has been the demonstration that the diverse cells within the immunological network communicate with each other not only by cell/cell contact but also by an array of hormone-like proteins te...