BACKGROUND Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. OBJECTIVE To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vi...

Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...

BACKGROUND Presentation with a firm type of chronic hepatomegaly of multifactorial etiology is common among school-age children in sub-Saharan Africa. OBJECTIVE Aflatoxin is a liver toxin and carcinogen contaminating staple maize food. In this study we examined its role in chronic hepatomegaly. METHODS Plasma samples collected in 2002 and again in 2004 from 218 children attending two school...

Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...

objective: aflatoxin is important in the food industry, in animal husbandry and the medical area; there are enormous negative economic impacts due to this toxin. numerous studies have researched extracts and plant compounds with the intent to reduce the growth of aflatoxin-producing organisms, inhibit toxin production and suppress the major toxin encoded genes (i.e., aflr) in these organisms. l...

This research investigated the optimal conditions of heat and chemical treatment for elimination aflatoxin. NaOH showed highest inhibition percentage (75.44%) Aspergillus flavus growth that was isolated from lowgrade maize. Low-grade maize contaminated with A. treated by varying three factors in levels: concentration (0, 2.5 5% w/v), temperature (25, 50 75°C) time (24, 48 72 h). Aflatoxin remov...

aflatoxins are carcinogenic metabolites produced by several strains of aspergillus flavus group in food and feed. cluster genes in aflatoxin biosynthesis pathway contain structural, regular and unassigned genes , nor-1 , ver-1 , and omt-1 are structural genes that coding for key enzymes and aflr is a regulatory gene that plays a key role in the production of aflatoxin and is affecting on the st...

Background: This cross sectional study was conducted to evaluate the effect of &gamma-rays and electron-beam irradiation with a commercial toxin binder-milbond-TX on the performance, feed components, and meat quality of Japanese quails challenged with aflatoxin B1. Methods: Overall, 168 One-d-old chicks (Japanese quails) were allocated to eight treatments with three replicates based on a com...

Efficacy of some local plants in the management of Aspergillus flavus and aflatoxin contamination was investigated. Aqueous extracts of rhizome of Zingiber officinalis and leaf extracts of Trigonella foenum-graecum inhibited aflatoxin production to a significant level. While solvent extracts of Zingiber officinalis and Oxalis corniculata could suppress both the growth and aflatoxin production b...

BACKGROUND Fumonisins and aflatoxins are mycotoxins that are produced by Fusarium and Aspergillus genus respectively. Due to the toxicity of aflatoxin and fumonisin and its effects on human and animals' health, the purpose of this study was analysis of total fumonisin and total aflatoxin contamination in biscuit and cookie samples in Babol City, Northern Iran. METHODS Thirty biscuit (n=15) an...