We propose a novel pathway for the prebiotic synthesis of 2'-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic amino acids, serine and cysteine, led us to explore the consequences of the corresponding sulfur substitution for our previously proposed pathways leading to the canonical...

There are two independent mol-ecules in the asymmetric unit of the title phen-oxy-ethanol derivative, C10H14O2, Each molecule has an approximately planar structure except for the hy-droxy groups (r.m.s. deviations = 0.0281 and 0.0144 Å). The ethyl-enedi-oxy groups have a gauche conformation. In the crystal, the mol-ecules form O-H⋯O hydrogen-bonded chains along the a axis.

acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). the reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecular cycloaddition while it was reacted with n-methyl aniline ...

To discover new 1,2,4-triazole derivatives which may possess significant biological activities, we synthesized a series of novel 6-aryl-3-(D-galactopentitol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines and 4-(arylmethylidene)amino-5-(D-galactopentitol-1-yl)-3-mercapto-4H-1,2,4-triazoles from 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole. All the title compounds were characte...

We have developed an absorption spectrum based molecular ruler that measures the distance between two mercapto groups. The conformation of the molecular rulers changes with the distance, which induces an absorption spectrum change. DFT calculation has been carried out to elucidate the relation between the molecular conformation and the absorption spectrum. With this simple method, we can estima...