Gonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal reproductive development and function. Evolutionarily conserved regulatory elements in the mouse, rat, and human Gnrh1 gene include three enhancers and the proximal promoter, which co...

A TOOL TO SUPPORT HEALTHCARE DECISION-MAKING AND REAL-WORLD EVIDENCE GENERATION Degli Esposti L1, Saragoni S1, Sangiorgi D1, Crovato E1, Blini V1, Buda S1, Paoli D1, Veronesi C1, Degli Esposti E1, Cangini A2, Russo P2 on the behalf of the OsMed Health-DB. 1CliCon S.r.l. Health, Economics & Outcomes Research, Ravenna, Italy; 2 Italian Medicines Agency (AIFA-Agenzia Italiana del Farmaco), Roma, I...

Introduction: The development of an effective vaccine against Hepatitis C virus (HCV) is still a target of intensive vaccine research. The HCV envelope proteins E1 and E2 which can induce broadly neutralizing antibodies are the major candidate for this purpose. Different types of expression systems have been used to express these glycoproteins. In this study, an expression system using Pichia p...

Abstract. According to Modern-Era Retrospective Research Analysis for and Applications (MERRA-2) temperature wind datasets in 2019, this study presents the global variations eastward-propagating wavenumber 1 (E1), 2 (E2), 3 (E3) 4 (E4) planetary waves (PWs) their diagnostic results polar middle atmosphere. We clearly demonstrate eastward wave modes exist during winter periods with westward back...

The stability problem of functional equations originated from a question of Ulam 1 concerning the stability of group homomorphisms. Hyers 2 gave a first affirmative partial answer to the question of Ulam for Banach spaces. Hyers’s theorem was generalized by Aoki 3 for additive mappings. In 1978, Rassias 4 generalized Hyers theorem by obtaining a unique linear mapping near an approximate additiv...

We present here the detection of dopamine (DA) at nanopipet electrodes with radii of hundreds of nanometers ranging from 160 nm to 480 nm. Dibenzo-18-crown-6 (DB18C6) was employed as an ionophore to facilitate DA transfer, resulting in a half-wave transfer potential, E1/2, DA, of -0.322 (±0.020) V vs. E1/2, TBA. Well-defined steady-state sigmoidal cyclic voltammograms were observed for the tran...

ion and function application employ the notion of substitution. Recall the inference rule and its representation in LF: e1 ↪→ lam x. e1 e2 ↪→ v2 [v2/x]e1 ↪→ v ev app e1 e2 ↪→ v ev app : ΠE1:exp. ΠE2:exp. ΠE′ 1:exp→ exp. ΠV2:exp. ΠV :exp. eval E1 (lam E′ 1) → eval E2 V2 → eval (E′ 1 V2) V → eval (app E1 E2) V. As before, we transcribe this (and the trivial rule for evaluating λ-expressions) into...