Full details of the template-directed covalent cross-linking of duplex oligodeoxynucleotides are presented. 4-Thio-2'-deoxyuridine was incorporated synthetically into a 17mer oligodeoxynucleotide, and the thiocarbonyl group of the modified base was alkylated with a variety of alpha-bromoacetyl-derivatized diamines. Covalent cross-linking was initiated by annealing the electrophilic probe oligom...

some new macrocyclic dibenzotetraoxadiamides, tribenzotetraoxadimides, tribenzopentaoxadiamide, tribenzohexaoxadiamide, and tetrabenzoheptaoxadiamide 15-22 have been prepared. these compounds were obtained in the macrocyclization step by reacting the diamines 6 and 7 with appropriate dicarboxylic acid dichlorides 8-14. the cyclization does not require high dilution techniques or template effect...

α-Nitro-δ-keto nitriles and α-nitro-δ-keto ester were readily converted to diazabicyclo compounds having vicinal functionality upon treatment with diamines. The keto nitrile attracts the diamine nearby to an acidic hydrogen to cause the pseudo-intramolecular imination which proceeds efficiently without any catalyst at room temperature.

The copolymerization of epoxides, including cyclohexene oxide and vinyl-cyclohexene oxide with carbon dioxide are presented. These processes are catalyzed using a homogeneous di-zinc complex that shows good activity and very high selectivities for polycarbonate polyol formation. The polymerizations are investigated in the presence of different amounts of exogenous reagents, including water, dio...

The condensation of dehydroacetic acid and 4-hydroxy-6-methylpyran-2-one with primary diamine derivatives such as hydrazine, 1,2-diaminoethane 1,6-diaminohexane yielded bispyrone bispyridone has been reported. hydrazine in acetonitrile generated another bispyrazole product but n-butanol, this reaction afforded the bispyridones. structures synthesized bispyrazoles were examined by spectroscopy X...

five new aromatic poly(amide-imide)s (5a-e) were synthesized by direct polycondensationreaction of n-(4-carboxy phenyl) trimellitimide (3) with five aromatic diamines (4a-e) by usingtriphenyl phosphite in n-methyl-2-pyrrolidone (nmp) and pyridine at solution containingdissolved cacl2. all of the polymers were obtained in quantitative yields with inherentviscosities between 0.29-0.40 dl/g. the r...

The aromatic diamine 4-aminopyridine was used for the synthesis of a series supramolecular metal–organic sulfate salts. obtained compounds with formula (C5H7N2)2[MII(H2O)6](SO4)2 (MII = Fe, Co, Ni, Cu and Zn) (C5H7N2)2[Mn(H2O)4(SO4)2] crystallize triclinic symmetry (S.G. P $$\overline{1 }$$ ). These complexes possess hybrid structure type an interlayer distance that varies from 10 to 12 Å depen...

Quinazolines have long been known to exert varied pharmacologic activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, we synthesized approximately 150 different 6,7-dimethoxyquinazoline-2,4-diamines evaluated their antimalarial activity via structure-activity relationship studies. Here, summarize the results report discovery of 6...

In this work, the crosslinking reaction of partially carbonated epoxidized soybean oils with diamines was investigated through an unprecedented combination in situ infrared and Raman spectroscopies, revealing two regimes.

Six alkali metal tris(HMDS) magnesiate complexes (HMDS, 1,1,1,3,3,3,-hexamethyldisilazide) containing chiral diamine ligands have been prepared and characterised in both the solid- and solution-state. Four of the complexes have a solvent-separated ion pair composition of the form [{M·(chiral diamine)(2)}(+){Mg(HMDS)(3)}(-)] [M = Li for 1 and 3, Na for 2 and 4; chiral diamine = (-)-sparteine for...