Q. Shen, H. Ren, T. Q. Duong Yerkes Primate Research Center, Emory Unviersity, Atlanta, GA, United States Introduction The intricate neural-vascular coupling associated with changes in neural activity forms the basis for many modern neuroimaging modalities. However, the temporal dynamics of the stimulus-evoked CBF and CBV responses and the resulting BOLD signals remain poorly understood and som...

OBJECTIVE To evaluate the efficacy and safety of three dosing and repeat treatment regimens of rituximab (RTX) plus MTX in patients with active RA. METHODS Patients with active RA despite stable MTX (10-25 mg/week) were randomly assigned to one of the three treatment regimens comprising two courses of RTX given 24 weeks apart: 2 x 500 and 2 x 500 mg; 2 x 500 and 2 x 1000 mg (dose escalation);...

PURPOSE To investigate the temporal dynamics of blood oxygenation level-dependent (BOLD), cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral metabolic rate of oxygen (CMRO(2)) changes due to forepaw stimulation with 500-msec resolution in a single setting. MATERIALS AND METHODS Forepaw stimulation and hypercapnic challenge on rats were studied. CBF and BOLD functional MRI (f...

On a clinical basis, severe insulin resistance is defined as a situation in which a patient requires 200 units of insulin daily for 2 days (1). This definition was determined 50 years ago, when it was erroneously believed that the human pancreas secreted 200 units of insulin a day. Although it is now known that the normal pancreas secretes only 20–40 units of insulin a day, this clinical defini...

Some patients with type 2 diabetes mellitus (T2DM) are profoundly insulin resistant and require large insulin doses to achieve optimal glycaemic control. However, large volumes of subcutaneous conventional U-100 insulin can cause discomfort at the injection site, resulting in poor concordance with insulin therapy. One therapeutic option is the use of U-500 insulin, thus reducing the insulin vol...

Glimepiride/metformin(2/500mg) is an oral antihyperglycemic agent for the treatment of type 2 diabetes. A generic glimepiride/metformin(2/500mg) fixed-dose combination(FDC) tablet was developed recently. This study was designed to collect data for submission to Korean regulatory authorities to allow the marketing of the test formulation. We evaluated the comparative bioavailability and tolerabi...

5-Axis milling simulations in CAM software are mainly used to detect collisions between the tool and the part. They are very limited in terms of surface topography investigations to validate machining strategies as well as machining parameters such as chordal deviation, scallop height and tool feed. Z-buffer or N-Buffer machining simulations provide more precise simulations but require long com...

OBJECTIVE Phase-separation within HEMA-free all-in-one dental adhesives may result in the entrapment of droplets within the adhesive resin. Strongly air-blowing prior to polymerization, can remove most of these droplets. The objective of this study was to evaluate the effect these droplets may have on the resistance of the adhesive-tooth interface to NaOCl degradation. METHODS The micro-tensi...

Nowadays architectures and their programming model implementations are becoming increasingly complex and diverse, making the performance benefits of using local memory unpredictable via only simplistic modeling. In this paper, we present a benchmark-based approach to tackle this issue. We first present a two-part approach to describe memory access patterns for many-thread applications. For each...