Watts, Stephanie W., and Gregory D. Fink. 5-HT2Breceptor antagonist LY-272015 is antihypertensive in DOCAsalt-hypertensive rats. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H944–H952, 1999.—We previously demonstrated a change in the receptors mediating 5-hydroxytryptamine (5-HT)-induced contraction in arteries of deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Specifically, contra...

Ray, Ramesh M., Barbara J. Zimmerman, Shirley A. McCormack, Tarun B. Patel, and Leonard R. Johnson. Polyamine depletion arrests cell cycle and induces inhibitors p21Waf1/Cip1, p27Kip1, and p53 in IEC-6 cells. Am. J. Physiol. 276 (Cell Physiol. 45): C684–C691, 1999.—The polyamines spermidine and spermine and their precursor putrescine are intimately involved in and are required for cell growth a...

Hardt, Stefan E., Armin Just, Raffi Bekeredjian, Wolfgang Kübler, Hartmut R. Kirchheim, and Helmut F. Kuecherer. Aortic pressure-diameter relationship assessed by intravascular ultrasound: experimental validation in dogs. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1078– H1085, 1999.—Intravascular ultrasound (IVUS) has emerged as an important diagnostic method for evaluating vessel diameter...

Marples, David, Jørgen Frøkiaer, and Søren Nielsen. Long-term regulation of aquaporins in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F331–F339, 1999.—The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct w...

Francis, Noelle,Alain Cohen-Solal, and Damien Logeart. Peripheral muscle ergoreceptors and ventilatory response during exercise recovery in heart failure. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H913–H917, 1999.— Recent studies have suggested that the increased ventilatory response during exercise in patients with chronic heart failure was related to the activation of muscle metaborecept...

Mukkamala, Ramakrishna, Joanne M. Mathias, Thomas J. Mullen, Richard J. Cohen, and Roy Freeman. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R905–R912, 1999.—We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patien...

Bestle, Morten Heiberg, Niels Vidiendal Olsen, Poul Christensen, Benny Vittrup Jensen, and Peter Bie. Cardiovascular, endocrine, and renal effects of urodilatin in normal humans. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R684–R695, 1999.—Effects of urodilatin (5, 10, 20, and 40 ng·kg21 ·min21) infused over 2 h on separate study days were studied in eight normal subjects wi...

Jin, Lan, Lee Chao, and Julie Chao. Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2 receptor in SHR. Am. J. Physiol. 276 (Renal Physiol. 45): F476–F484, 1999.—High potassium intake is known to attenuate hypertension, glomerular lesion, ischemic damage, and stroke-associated death. Our recent studies showed that expression of recombinant kallikrein by somati...

Kriston, Tünde, Rocco C. Venuto, Christine Baylis, and György Losonczy. Hemodynamic and renal effects of U-46619, a TXA2/PGH2 analog, in late-pregnant rats. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R831–R837, 1999.—The vasoconstrictor effects of pressor agents are attenuated during pregnancy. Thromboxane A2 (TXA2) is produced in great quantities during hypertension in pre...