We show that the 2D quasi-geostrophic equation has global and unique strong solution when the (large) data belongs in the critical scale invariant space Ḃ2−2α 2,∞ ∩ L2/(2α−1).

Abstract Background Immunotherapy is a standard-of-care first-line treatment for advanced clear cell renal carcinoma (ccRCC). However, many patients will develop resistance to therapy, and effective second- later-line options are therefore needed. The von Hippel-Lindau (VHL) gene inactivated in approximately 90% of with RCC results the constitutive activation hypoxia-inducible factor 2α (HIF-2α...

The structural elucidation of 2α-cyclodextrin/1-octanethiol, 2α-cyclodextrin/1-octylamine and 2α-cyclodextrin/1-nonanoic acid inclusion complexes by nuclear magnetic resonance (NMR) spectroscopy and molecular modeling has been achieved. The detailed spatial configurations are proposed for the three inclusion complexes based on 2D NMR method. ROESY experiments confirm the inclusion of guest mole...

– in this paper we consider some (α ,β ) -metrics such as generalized kropina, matsumoto and f (α β )2α = + metrics, and obtain necessary and sufficient conditions for them to be einstein metrics when βis a constant killing form. then we prove with this assumption that the mentioned einstein metrics must beriemannian or ricci flat.

An isospin analysis of B → ππ decays yields sin 2α, where α is the usual CKM angle α ≡ arg[−V td V * tb /(V ud V * ub)] without hadronic uncertainty if isospin is a perfect symmetry. Yet isospin symmetry is broken not only by electroweak effects but also by the u and d quark mass difference — the latter drives π 0 − η, η ′ mixing and converts the isospin-perfect triangle relation between the B ...

Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory distress syndrome (ARDS). Specifically, functionally active genetic variants of HIF-2α (single nucleotide polymorphism (SNP) [ch2:46441523(hg18)]) and PHD2 (C/T; SNP rs516651 and T/C; SNP rs480902) are associated with improved adaptation ...

Hypoxia-inducible factor 2α (HIF-2α) plays a pivotal role in the balancing of oxygen requirements throughout the body. The protein is a transcription factor that modulates the expression of a wide array of genes and, in turn, controls several key processes including energy metabolism, erythropoiesis and angiogenesis. We describe here the identification of two cases of familial erythrocytosis as...

Proliferation of adventitial fibroblasts of small intrapulmonary arteries (FBPA) has been disclosed as an early event in the development of pulmonary hypertension and cor pulmonale in response to hypoxia. We investigated the role of hypoxia-inducible transcription factors (HIF) in human FBPA exposed to hypoxia. Primary cultures of FBPA displayed a strong mitogenic response to 24 h hypoxia, wher...

BACKGROUND Endothelial dysfunction is considered as the initiating process and pathological basis of cardiovascular disease. Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS), inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) are key enzymes with opposing actions in inflammation and oxidative stress, which are believed to be the major driver of endothelial dysfunction. A...

Macrophage secretion of vascular endothelial growth factor (VEGF) in response to hypoxia contributes to tumor growth and angiogenesis. In addition to VEGF, hypoxic macrophages stimulated with GM-CSF secrete high levels of a soluble form of the VEGF receptor (sVEGFR-1), which neutralizes VEGF and inhibits its biological activity. Using mice with a monocyte/macrophage-selective deletion of hypoxi...