Moloney murine leukemia virus, disrupted in concentrations of 0.1 to 0.5% Nonidet P-40, catalyzed the cleavage of p65, the gag gene polyprotein of the Gazdar strain of murine sarcoma virus, into polypeptides with sizes and antigenic determinants of murine leukemia virus-specified p30, p15, pp12, and p10. Cleavage performed in the presence of 0.15% Nonidet P-40 in water yielded polypeptides of a...

BIOCHEMISTRY, MEDICAL SCIENCES. For the article ‘‘Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187,’’ by Scott Classen, Stephane Olland, and James M. Berger, which appeared in issue 19, September 16, 2003, of Proc. Natl. Acad. Sci. USA (100, 10629–10634; first published September 8, 2003; 10.1073 pnas.1832879100), the authors...

BACKGROUND Upper extremity musculoskeletal symptoms and disorders are common in the working population. The economic and social impact of such disorders is considerable. Long-time, dynamic repetitive exposure of the hand-arm system during manual handling operations (MHO) alone or in combination with static and postural effort are recognised as causes of musculoskeletal symptoms and disorders. T...