Department of Biology, Georgia Southern University, P.O. Box 8042, Statesboro, GA 30460, USA Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA Dauphin Island Sea Laboratory, 101 Bienville Boulevard, Dauphin Island, AL 36528, USA USDA Forest Service, Center for Forest Disturbance Science, 320 East Green Street, Athens, GA 30601, USA e Joseph W. Jones Ecological ...

Obesity is linked to increased risk of colon cancer, currently the third most common cancer. Consequently rising levels of obesity worldwide are likely to significantly impact on obesityrelated colon cancers in the decades to come. Understanding the molecular mechanisms whereby obesity increases colon cancer risk is thus a focus for research to inform strategies to prevent the increasing trend ...

Gene duplication and fusion are among the primary natural processes that generate new proteins from simpler ancestors. Here we adopted this strategy to evolve a promiscuous homohexameric 4-oxalocrotonate tautomerase (4-OT) into an efficient biocatalyst for enantioselective Michael reactions. We first designed tandem-fused 4-OT allow independent sequence diversification of adjacent subunits by d...

The hormonal responses to anaesthesia and cardiac surgery were studied in 20 patients. Ten patients were anaesthetized with fentanyl 60 microgram kg-1 and nitrous oxide in oxygen and 10 with etomidate 0.3 mgkg-1 and nitrous oxide in oxygen plus halothane. There were no significant changes in cortisol, growth hormone or insulin concentrations in response to surgery in either group, although cort...

In 14 patients undergoing open-heart operations the haemodynamic effects of diazepam 0.4 mgkg(-1) followed by ketamine 2 mg kg(-1) were studied. In eight patients undergoing coronary bypass surgery, the mean arterial pressure decreased significantly after diazepam from 90.3 +/-7.4 (SEM) to 78.0 +/-5.0 mm Hg (P less than 0.05). However, no changes occurred in six patients undergoing valve replac...

Background. Until now, the effect of arginine vasopressin (AVP) in the DMV on gastric motility and the possible modulating pathway between the DMV and the gastrointestinal system remain poorly understood. Objectives. We aimed to explore the role of AVP in the DMV in regulating gastric motility and the possible central and peripheral pathways. Material and Methods. Firstly, we microinjected diff...

effects of chromium nano particles (nanocr) on performance and meat quality of japanese quail under physiological stress was determined by  using 360 birds in a completely randomized design with six treatments, four replicates and 15 birds per each, during  17- 35 d of age. the tratments were negative control (non-stressed), and five groups under physiological stress which fed on diets suppleme...

Data from the Abeokuta Heart Failure Registry were used to determine the clinical characteristics, mode of treatment, and short- and medium-term outcomes of patients with hypertensive heart failure. A total of 320 patients were consecutively studied, comprising 184 men (57.5%) and 136 women (42.5%) aged 58.4±12.4 and 60.6±14.5 years, respectively. Most patients (80%) presented with New York Hea...

Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...