• The discovery of the first crown ether is described. Forty-seven other aromatic and saturated polyethers were synthesized and their properties determined. Many form stable crystalline complexes with alkali and alkaline earth salts. Some saturated crown ethers solubilize potassium hydroxide and permanganate in aromatic hydrocarbons, EThe SC!5 indicates that this paper has been cited in over 1,...

Dibenzo-2 1-crown-7 (DB2IC7) and dibenzo-24-crown-8 (DB24C8) have been used to extract the metal ions (Na+. K+. Mg2+ and Ca2+) present in bittern, schoenite and in an artificial solution containing equimolar amount of the above mentioned metal ions. Ion chromatographic study of the organic extract shows that DB21 C7 extracts potassium with hi gh selectivity, whereas DB24C8 extracts comparable a...

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.

Programming the sequence of functional units in redox-switchable hetero[3]rotaxanes is achieved by integrative self-sorting for a library five crown ethers.

The reaction of Pb[BF(4)](2) in H(2)O/MeCN solution with the macrocycle 18-crown-6 gave the dinuclear complex [{Pb(18-crown-6)(H(2)O)(μ(2)-BF(4))}(2)][BF(4)](2), containing two nine-coordinate lead centres, each bound to all six oxygens of a crown ligand, one water molecule and bridged by two μ(2)-BF(4) groups. In contrast, the oxa-thia crown [18]aneO(4)S(2) gave the mononuclear [Pb([18]aneO(4)...

The processes involved in transport of K and Na by the carrier ionophores valinomycin and 18-crown-6 ether across cell membranes have been elucidated using quantum mechanical modelling: 1. Formation of the {ionophore-M} complex: desolvation (ΔGdesolv) of the central cavity of the ionophore, change in configurational energy TΔS, desolvation of the M(H2O)6-7 + 2. Desolvation of the {ionophore-M} ...