To clarify the molecular interaction of irinotecan (CPT-11) and oxaliplatin (l-OHP) in combination with 5-fluorouracil (5-FU), the antitumor effects of CPT-11 and l-OHP combined with the oral 5-FU prodrug, S-1 composed by tegafur, gimeracil and potassium oteracil, were investigated on human colon cancer KM12C xenografts sensitive or resistant to 5-FU in nude mice. In parental KM12C tumor xenogr...

Measurement of 17-hydroxyprogesterone (17-OHP) in daily dried blood spot profiles via radioimmunoassay is a convenient and accepted method for monitoring of glucocorticoid therapy in Congenital Adrenal Hyperplasia. Characteristics of this method that serve to limit its clinical usefulness include its lack of specificity for 17-OHP, and a relatively high limit of detection. Mass Spectroscopy is ...

Objectives-To assess environmental exposure to polycyclic aromatic hydrocarbons (PAHs) in the vicinity ofa Soderberg aluminium reduction plant in Shawinigan, Canada with urinary 1-hydroxypyrene (1-OHP) as a biomarker. Methods-Urine samples were collected from 20 non-occupationally exposed subjects living less than 500 m from the plant and from 20 controls living in TroisRivieres, another indust...

tion in nmol/L and x is the year of collection). In the autoclaved cards, 17-OHP concentrations were 27.3% lower than in the native cards: median (25th–75th percentiles), 5.6 (3.6–8.9) nmol/L vs 7.7 (5.3–11.1) nmol/L; P 0.001. Thus, 17-OHP in dried blood spots on autoclaved or native filter-paper cards decreased 2–3% annually, and the decrease was significant on native cards but not on autoclav...

OBJECTIVE To estimate the reported incidence of occupational hypersensitivity pneumonitis (OHP) in the UK and to consider whether the pattern of attributed causation has changed over time. METHODS All cases of OHP reported to the SWORD scheme between January 1996 and December 2015 were classified into 1 of 10 categories of the suspected agent. Cases were grouped into four 5-year time periods ...

BACKGROUND Reports have shown that normotensive offspring of hypertensive parents (OHP) are at increased risk of developing systemic hypertension (SH) and adverse cardiovascular events later in life. The pathological antecedents of this are thought to be alterations in the structure and function of left ventricle. Therefore, the present study aimed at determining left ventricular mass and geome...

the objective of this study was to determine the efficacy of two procedures i.e. feeding and immersion followed by feeding, for masculinizing blue hap. two experiments (experiments i and ii) were conducted. in experiment i, feeding hormonal treatment was applied on post-yolk sac stage fry (10 days after fertilization at 27ºc). dosages of 30mg (group a) and 60mg (group b) of 17α-methyltestostero...

For the purpose of prenatal diagnosis of CAH, genetic linkage analysis by HLA genotyping with lymphocytes and cultured amniotic cells were performed in a family at risk in which two consecutive children had been affected with SW CAH. In addition, the response of serum 17-OHP to intravenous ACTH was determined in obligate carrier parents, and 17-OHP concentration of amniotic fluid was also measu...

Certain human biotransformation enzymes have been implicated in the formation and scavenging of the ultimate reactive metabolites, the diolepoxides, from polycyclic aromatic hydrocarbons (PAHs). In the present study, performed on aluminum smelter workers, we have analyzed airborne PAH, the pyrene metabolite 1-hydroxypyrene (1-OHP) in urine, and genotypes for biotransformation enzymes involved i...