Aminoglycosides are still widely used for treatment of gram-negative sepsis in critically ill patients. The most reported electrolyte abnormalities related to these drugs are hypokalemia, hypomagnesemia, and hypocalcemia. In this study potential benefit of atorvastatin in prevention of amikacin-induced electrolytes imbalances has been evaluated. In this trial 44 patients were assigned to the at...

Plasma catecholamine and renin activity levels were measured across a range of dietary sodium intakes (10--300 mEq/day) in 20 normal male volunteers. Supine plasma norepinephrine levels presented a triphasic pattern in relation to urine sodium, whereas epinephrine levels were not significantly altered by sodium intake, and renin showed the well-known hyperbolic relationship to urine sodium excr...

The duration of untreated (no cardiopulmonary resuscitation) ventricular fibrillation (VF) needed to produce postdefibrillation pulseless electrical activity (PEA) was determined in 9 anesthetized swine ranging in weight from 20 to 30 kg. VF was induced electrically by a right ventricular catheter electrode, while arterial pressure and the electrocardiogram were recorded. VF was confirmed by th...

For soldiers, surviving the war, increasing their mission capability rates, and physical fitness levels such as endurance, strength, mobility, and flexibility are important (1). In particular, endurance is an important physical fitness factor essential while soldiers perform their missions (1). Blood lactate threshold (LT) is an excellent pre-dictor of an individual's endurance capacity (2); th...

Experiments were performed on conscious uninephrectomized dogs to determine the comparative effects of chronic intrarenal and intravenous norephrine (NE) infusion (0.27 microgram/kg/min) on the steady-state values for arterial pressure, plasma renin activity (PRA), and renal function at four levels of sodium intake (5, 40, 120 and 240 mEq/day). Arterial pressure was monitored continuously 24 hr...

Weight increase is a common side-effect after chronic lithium salt treatment in man. This effect has not always been found in animal models using the rat. The possibility that the age and sex of animals might interfere with the results was studied, using groups of male and female rats, 2, 5, and 12 months old, injected intraperitoneally twice daily for 28 days with a solution of lithium chlorid...

Dogs with thoracic caval constriction retain sodium and develop ascites and edema. The role of the renin-angiotensin-aldosterone system in this model of low output failure was evaluated before, during, and after administration of the new orally active converting enzyme inhibitor, 2-D-methyl-3-mercaptopropanoyl-L-proline (SQ 14225). The acute response to the initial oral dose of SQ 14225 (10 mg/...

iodine deficiency disorders are among the most important health problems in iran. use of iodized salt is one of the oldest, most convenient and cheapest ways of idd control, although not very easy to implement. factors such as the chemical form of iodine, heat moisture, light and storage affect its stability. in this survey, salt iodine content at production site and the effect of heat, moistur...

AIMS Chronic excess salt intake may have blood pressure-independent adverse effects on the heart such as myocardial hypertrophy and fibrosis. Effects of subacute sodium loading with excess dietary salt on diastolic function in normotensive individuals have been conflicting and the mechanisms are poorly understood. METHODS AND RESULTS Thirteen healthy normotensive subjects (age 24 ± 4 years) e...