BACKGROUND AND PURPOSE We investigated the combined effect of tissue plasminogen activator and ischemia on middle cerebral artery (MCA) reactivity to determine whether abnormal MCA function after 2 hours of ischemia was worse in arteries perfused with recombinant tissue plasminogen activator (rtPA). METHODS The intraluminal suture model of focal cerebral ischemia was used to induce 2 hours of...

BACKGROUND The role of high-dose dexamethasone in the treatment of immune thrombocytopenic purpura in adults is controversial. We assessed the effectiveness of high-dose dexamethasone as initial treatment in a series of consecutive adults with immune thrombocytopenic purpura. METHODS Consecutive patients with newly diagnosed immune thrombocytopenic purpura and a platelet count of less than 20...

The past 5 years have seen an explosion of knowledge about miRNAs and their roles in hematopoiesis, cancer, and other diseases. In myeloid development, there is a growing appreciation for both the importance of particular miRNAs and the unique features of myelopoiesis that are being uncovered by experimental manipulation of miRNAs. Here, we review in detail the roles played by 4 miRNAs, miR-125...

Plant cell suspension cultures are widely used for the production of recombinant proteins and secondary metabolites. One of the most important steps during process development is the optimization of yields by testing different cultivation parameters, including the components of the growth medium. However, we have shown that the biomass yield of a cell suspension culture derived from the pear cu...

Introduction § 0. Preliminaries: fuzzy sets 125 § 1. Fuzzy topological spaces: the basic categories of fuzzy topology 127 § 2. Fundamental interrelations between the category Top of topological 135 spaces and the categories of fuzzy topology § 3. Local structure of fuzzy topological spaces 138 § 4. Convergence structures in fuzzy spaces 140 § 5. Separation in fuzzy spaces 143 § 6. Normality and...

To study delphinid near surface movements and behavior, two L-shaped hydrophone arrays and one vertical hydrophone line array were deployed at shallow depths (<125 m) from the floating instrument platform R/P FLIP, moored northwest of San Clemente Island in the Southern California Bight. A three-dimensional propagation-model based passive acoustic tracking method was developed and used to track...

Paediatr Suppl 1999;88:200–8. 21. Wajnrajch MP, Gertner JM, Mullis PE, Deladoëy J, Cogan JD, Lekhakula S, et al. ARGHIS is a new mutational “hot-spot” in the growth hormone (GH) gene causing isolated GH deficiency type II. J Endocr Genet 2001;1:125– 35. 22. Wada M, Uchida H, Ikeda M, Tsunekawa B, Naito N, Banba S, et al. The 20-kilodalton (kDA) human growth hormone (hGH) differs from the 22-kDA...

VIIINTRODUCTION1II. THE CONCEPTUAL FRAMEWORK14III. U.S. SAMPLE AND MEASURES21IV. ASSESSING RELEVANCE ACROSS TIME: U.S. ANALYSES AND RESULTS26V ASSESSING RELEVANCE ACROSS CULTURE: CROSS-NATIONAL REPLICATIONS 58VI. ASSESSING RELEVANCE ACROSS METHOD: U.S. DOMINANCE ANALYSES73VII. ASSESSING RELEVANCE ACROSS METHOD: CROSS-NATIONAL DOMINANCEANAL...