Oral lichen planus (OLP) is a common oral mucosal disease, which is generally considered a potentially malignant lesion. To identify efficiently prognostic biomarker, we investigated the microRNA-137 (miR-137) promoter methylation in OLP and compared with the samples from healthy volunteers and patients with oral squamous cell carcinoma (OSCC). A total of 20 OLP and 12 patients with OSCC as wel...

Background and purpose When treating lung tumors with stereotactic body radiation therapy (SBRT), patient immobilization is of outmost importance. In this study, the intra-fractional shifts (based on bony anatomy) tumor visible target volume) are quantified, associated impact delivered dose estimated for a frameless approach in combination surface guided (SGRT) monitoring. Methods Cone beam com...

In Belarus's Gomel region, which was heavily contaminated by fallout from the Chernobyl disaster, we have studied the evolution of the Cs-137 load in the organisms of the rural population, in particular children, since 1990. Children have a higher average burden of Cs-137 compared with that of adults living in the same community. We measured the Cs-137 levels in organs examined at autopsy. The ...

We compared the performances of three hepatitis C virus genotyping methodologies supplied by Bayer, Abbott, and Third Wave Technologies. Genotypes were determined for 136 of 137 specimens by the Bayer method, 121 of 137 specimens by the Invader assay, and only 77 of 137 specimens by the Abbott assay. All reported genotypes were concordant by all three methods.

Multidrug resistance (MDR) to chemotherapeutic agents is a major obstacle to successful treatment in breast cancer patients. The aims of this study were to investigate whether miR-137 was involved in the regulation of MDR, and to explore the mechanism of miR-137 on the sensitivity of MCF-7/ADM cells. miR-137 was downregulated in MCF-7/ADM cells, and its expression was found to inversely correla...