Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the bnAbs PGT121-134 and found a positive correlation between the level of somatic hypermutation (SHM) and the development of neutralization breadth an...

In order to understand the bioaccumulation of (241)Am and (134)Cs in scallops living in sediments, the uptake and depuration kinetics of these two elements were investigated in the king scallop Pecten maximus exposed via seawater, food, or sediment under laboratory conditions. Generally, (241)Am accumulation was higher and its retention was stronger than (134)Cs. This was especially obvious whe...

The metopic suture is located between the tubercles of the frontal bone. There are divergences regarding the exact time at which it closes, which ranges from the first to the tenth year of life, although it may persist into adulthood. This study was conducted on 134 dry crania from adult Brazilians, of which 95 were male and 39 were female. These were available in the anatomy laboratories of hi...

MicroRNAs (miRNAs) are small, single-stranded, non-coding RNAs that play pivotal roles in human cancer development and progression, such as tumor metastasis. Here, we identified the miRNAs that regulate hepatocellular carcinoma (HCC) cell migration by a high-throughput screening method using the classical wound-healing assay with time-lapse video microscopy and validation with a transwell migra...

BACKGROUND Temporal lobe epilepsy is the second most common neurological disorders characterized by recurrent spontaneous seizures. MicroRNAs play a vital role in regulating synaptic plasticity, brain development and post-transcriptional expression of proteins. In both animal models of epilepsy and human patients, miR-134, a brain-specific microRNA has recently been identified as a potential re...

Grown by Pulsed Laser Deposition Jae-Min MYOUNG1, Wook-Hi YOON, Dong-Hi LEE, Ilgu YUN, Sang-Hyuck BAE and Sang-Yeol LEE Information and Electronic Materials Research Laboratory, Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-Dong, Seodaemun-Gu, Seoul 120-749, Korea Department of Electrical and Electronic Engineering, Yonsei University, 134 Shinchon-Dong, Seodae...