BACKGROUND Identifying the septal versus lateral site of origin of ventricular tachycardia (VT) with a right bundle-branch block (RBBB)-type pattern and an R-S ratio >1 in lead V1 is difficult with the 12-lead ECG, especially in patients with prior apical infarction. METHODS AND RESULTS We prospectively evaluated 58 patients with VT. Sixteen patients had apical infarcts (group 1), 29 had nona...

Multiple sclerosis (MS) is associated with loss of skeletal muscle mass and function. The myogenic stem cells (satellite cells-SCs) are instrumental to accretion of myonuclei, but remain to be investigated in MS. The present study aimed to compare the SC and myonuclei content between MS patients (n = 23) and age matched healthy controls (HC, n = 18). Furthermore, the effects of 12 weeks of high...

BACKGROUND Fingolimod efficiently reduces multiple sclerosis (MS) relapse by inhibiting lymphocyte egress from lymph nodes through down-modulation of sphingosine 1-phosphate (S1P) receptors. We aimed to clarify the alterations in peripheral blood T cell subsets associated with MS relapse on fingolimod. METHODS/PRINCIPAL FINDINGS Blood samples successively collected from 23 relapsing-remitting...

We examined the time course of threshold reduction in the Gabor lateral masking paradigm. Contrast detection thresholds were measured (2AFC) for a briefly presented (36 ms) foveal Gabor signal (GS), preceded by a presentation (90 ms) of two high-contrast GS flanked masks, with stimulus onset asynchrony (SOA) varying from 0 to 16,290 ms. Using target-to-mask separations of 3 lambda and 12 lambda...

There are well over 500 registered pesticides worldwide for use in agricultural regions and new agrochemicals are introduced to the marketplace continuously. This chapter deals with the chemical analysis methods for the main pesticide chemical classes that are most frequently analyzed with gas chromatography (GC) or liquid chromatography (LC) coupled to mass spectrometry (MS). GC amenable pesti...

The aim of the study was to detect changes of the QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and body surface potential mapping (BSPM) recordings were obtained using Cardiag 112.2 diagnostic system from 27 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From...

According to median sensory nerve action potential onset-latency to index finger in a 140 mm fixed distance, 993 carpal tunnel syndrome (CTS) hands from 668 patients were grouped into MIld (3.0 to 3.5 ms, 384 hands). MOderate (3.6 to 4.4 ms, 332 hands), SEvere (> 4.4 ms, 135 hands) and UNrecordable (142 hands) and correlated with CTS symptomatology duration. All patients have sensory antidromic...