Antibodies capable of inhibiting the invasion of Plasmodium merozoites into erythrocytes are present in individuals that are clinically immune to the malaria parasite. Those targeting the 19-kD COOH-terminal domain of the major merozoite surface protein (MSP)-119 are a major component of this inhibitory activity. However, it has been difficult to assess the overall relevance of such antibodies ...

In an attempt to better understand and control the processes that regulate stem cell fate, we have set out to identify small molecules that induce neuronal differentiation in embryonic stem cells (ESCs). A high-throughput phenotypic cell-based screen of kinase-directed combinatorial libraries led to the discovery of TWS119, a 4,6-disubstituted pyrrolopyrimidine that can induce neurogenesis in m...

This research is an experimental study that aims to analyze and valuate the physical properties of rocks in Maros Pangkep Karst Area. The samples were 60 (sixty) consisted each 30 (thirty) Area (04°58'-05°01' S 119°39'-119°41' E) (04°51'-04°53' 119°37'-119°38' E). analysis results obtained modified limestone dolomite with density values range 1.50-2.68 g/cm3 porosity 0-50%, indicating secondary...

Background and objectives: The COVID-19 pandemic has put strain on the activities well-being of health care workers. We aimed to measure direct indirect impact a personal professional level for paediatric trainees in Flanders, Belgium.Study design: Junior representatives Flemish Society Paediatrics (Jong VVK) conducted longitudinal study among their fellow trainees. daily tasks, education emoti...

119 Decompressive Craniectomy for Posterior Reversible Encephalopathy Syndrome Abstract Type: Case Report/Case Series Amy I. Lee, M.D.; Patrick Shih, M.D.; John C. Liu, M.D. Northwestern University Posterior reversible encephalopathy syndrome (PRES) is a poorly understood, rare condition associated with obstetrical deliveries. Medical management is directed at treatment of the underlying cause ...

f’mpose Eagonists and tWockers are widely used grstemttcaUy for a variety of dtwases, pmductng tear productton alterattons. The effect of vatious either selective 0r tixed abkcken and sagoni~ts 0” ta productton of the rabbit lacrimal gland was investtgated Method Tear Row was determined by of a direct cannulatton of the excretory duct of the rabbit lacrimal gkmd. for up to 90 tin, under pentoba...

The mechanism by which myristoylated proteins are targeted to specific subcellular membrane compartments is poorly understood. Two novel acyl-binding proteins, UNC119A and UNC119B, have been shown recently to function as chaperones/co-factors in the transport of myristoylated G protein α-subunits and src-type tyrosine kinases. UNC119 polypeptides feature an immunoglobulin-like β-sandwich fold t...

We study the maximal compact subgroup K(E 9) of the affine Lie group E 9(9) and its on-shell realization as an R symmetry of maximal N = 16 supergravity in two dimensions. We first give a rigorous definition of the group K(E 9), which lives on the double cover of the spectral parameter plane, and show that the infinitesimal action of K(E 9) on the chiral components of the bosons and the fermion...

The dynamics of image-potential states on Cu(119) have been studied with two-photon photoemission. Direction-dependent quasielastic scattering processes with large momentum transfer are attributed to the finite terrace-width distribution on the stepped surface. This effectively couples image-potential states via interband scattering and leads to an asymmetry of the decay rate. Electrons in the ...

Effects of Aerosol Inhalation by the E‐Cigarette User 100 Dose and Effects of Inhaling Aerosolized Nicotine 100 Aerosolized Nicotine and Cardiovascular Function 101 Aerosolized Nicotine and Dependence 102 Effects of Nicotine in Youth Users 104 Nicotine Exposure from Maternal Nicotine Consumption: Prenatal and Postnatal Health Outcomes 108 Summary 113 Effects of the Inhalation of Aerosol Constit...