Islet amyloid polypeptide (IAPP) (amylin), the major component of islet amyloid, is produced by cleavage at the COOH- and NH(2)-termini of its precursor, proIAPP, likely by the beta-cell prohormone convertases (PC) 1/3 and PC2. Mice lacking PC2 can process proIAPP at its COOH- but not its NH(2)-terminal cleavage site, suggesting that PC1/3 is capable of initiating proIAPP cleavage at its COOH-t...

13 Proof: R private (f) C private (f) since in any protocol the parties send at least one bit per round. On the other hand, for every privately computable function f the bound R private (f) is achieved by the protocol A f. In any round of this protocol the parties send a message with size at most n. (Note that in steps (2a) and (2b) of A f we may save one bit per round by omitting the most sign...

First-principles total energy calculations and experimental measurements were performed to study the surface reconstructions of magnetostrictive Fe3Ga alloy. The behavior was evaluated in bulk by compressing stretching its lattice parameter. Results demonstrate two thermodynamically stable surfaces, 1x1 3x1 reconstructions. is an ideally FeGa terminated whereas also but it has a first-layer Fe ...

The aim of this study was to model the fatty acid composition of vegetable oils by using the adaptive neuro fuzzy inference system (ANFIS) and artificial neural network (ANN) based on rheological measurements. For this aim, seven different refined vegetable oils (hazelnut, soybean, sunflower, olive, canola, corn, and cotton seed) were used. Olive oil had the highest viscosity value of 0.067 Pa ...

Regulation of energy balance by leptin involves regulation of several neuropeptides, including thyrotropin-releasing hormone (TRH). Synthesized from a larger inactive precursor, its maturation requires proteolytic cleavage by prohormone convertases 1 and 2 (PC1 and PC2). Since this maturation in response to leptin requires prohormone processing, we hypothesized that leptin might regulate hypoth...

Background Although science findings and treatment approaches of a concussion have changed in recent years, there continue to be challenges in understanding the nature of the post-concussion behavior. There is growing a body of evidence that some deficits can be related to an impaired auditory processing. Purpose To assess auditory comprehension changes over time following sport-related concu...

A positional scanning synthetic peptide combinatorial library containing approximately 52 million hexapeptides was used to identify potential inhibitory peptides for recombinant mouse prohormone convertase 1 (PC1) and PC2 and to provide information on the specificity of these enzymes. The library surveys revealed that a P6 Leu, a P4 Arg, a P2 Lys, and a P1 Arg were most inhibitory against PC1, ...

The examples in Figure 16 and Figure 17 demonstrate how system errors have a cascading effect, resulting in multiple errors being introduced into a single hypothesis string. The alignment examples shown are, by design, easy to understand and are easily derived. In practice, multiple errors frequently occur in a single hypothesis string resulting in many different possible alignments. The Scorin...