104

UNC-104 (KIF1A) is a kinesin motor that transports synaptic vesicles from the neuronal cell body to the terminal. Previous in vitro studies have shown that a Dictyostelium relative of UNC-104 transports liposomes containing acidic phospholipids, but whether this interaction is needed for the recognition and transport of synaptic vesicles in metazoans remains unexplored. Here, we have introduced...

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The human leukemic T-cell line, TALL-104, is cytotoxic to human malignant brain tumors and traffics through brain tissue: implications for local adoptive immunotherapy.

Journal: :Cancer research 2000

C A Kruse S Visonneau B K Kleinschmidt-DeMasters C J Gup G G Gomez D B Paul D Santoli

Preclinical studies with the human MHC nonrestricted cytotoxic T-cell leukemic line, TALL-104, were performed in anticipation of its use in cellular immunotherapy trials for primary malignant brain tumors. In this study, we have: (a) quantitated the in vitro brain tumor cell lysis; (b) measured the cytokine secretion upon coincubation of TALL-104 cells with brain tumor cells; (c) investigated t...

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Tissue: Implications for Local Adoptive Immunotherapy Human Malignant Brain Tumors and Traffics through Brain The Human Leukemic T-Cell Line, TALL-104, Is Cytotoxic to

2000

Carol A. Kruse Sophie Visonneau Bette K. Kleinschmidt-DeMasters Carol J. Gup German G. Gomez David B. Paul Daniela Santoli

Preclinical studies with the human MHC nonrestricted cytotoxic T-cell leukemic line, TALL-104, were performed in anticipation of its use in cellular immunotherapy trials for primary malignant brain tumors. In this study, we have: (a) quantitated the in vitro brain tumor cell lysis; (b) measured the cytokine secretion upon coincubation of TALL-104 cells with brain tumor cells; (c) investigated t...

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