In this paper, to the best of our knowledge, we propose first multi-rate Nyquist-subcarriers modulation (SCM) for C-band 100Gbit/s signal transmission over 50km dispersion-uncompensated link. Chromatic dispersion (CD) introduces severe spectral nulls on optical double-sideband signal, which greatly degrades performance intensity-modulation and direct-detection systems. Based prior knowledge dis...