introduction: we investigated the role of atp-sensitive potassium channels and l-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. methods: we used a hotplate apparatus to assess pain behavior in male nmri mice. nociceptive sensitization was induced by three days injection of morphine and five days of drug free. on day 9 of the schedule, pain behavior test ...

BACKGROUND The purpose of this study was to determine the adequate loading and maintenance doses of N-acetylcyseteine (NAC) for patients suffering from acute ROS-induced injury. METHODS Concentrations of extra cellular NAC, cysteine (Cys), cystine (Cyst2), and methionine (Met) were measured in vitro, at which more than 50% of the intracellular ROS raised by paraquat were suppressed using Swis...

The novel neuronal nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl)imidazole (TRIM) and 7-nitro indazole (7-NI), were used to investigate the role of nitric oxide in a model of transient focal cerebral ischemia in vivo. In halothane-anesthetized rats, the middle cerebral artery (MCA) was occluded for 2 hours using an intravascular thread and then reperfused for 22 hours before hist...

L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), has been shown to have neuroprotective effects on cerebral ischemic, vascular dementia and amyloid-beta (Abeta)-induced animal models by inhibiting oxidative injury, neuronal apoptosis and glial activation, regulating amyloid-beta protein precursor (AbetaPP) processing and reducing Abeta generation. T...

This study was conducted to investigate the effects of L-carnitine and different levels of animal fat on performance, carcass characteristics and some blood parameters of broiler chickens. Two hundred one-day old male broiler chicks were allotted to5 treatments in 4 replicates and 10 birds in each replicate. Dietary treatments consisted of: 1) diet with 5% vegetable oil (T1), 2) diet with 5% ve...

This project was designed to titrate the influence of pyridostigmine injected intraarterially on pulmonary resistance and gas exchange in pigs and dogs. Pyridostigmine at 1 mg/kg reduced red blood cell cholinesterase activity 28-35% that was not significantly reduced further with doses up to 9 mg/kg. Plasma cholinesterase was reduced by 80% in the dog and 40% in the pig with 1 mg/kg of pyridost...