Expression of the cancer-germline (CG) (or cancer-testis) antigen gene BORIS/CTCFL has been proposed to mediate activation of CG antigen genes in cancer. Consistent with this idea, we have observed that BORIS is frequently expressed in ovarian cancer, often in conjunction with other CG genes. Here we assessed the role of BORIS in CG antigen gene regulation and DNA methylation using normal and c...

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One could think of many reasons where transforming a data set at hand to a lowdimensional space might be desirable, e.g. it makes the data easier to manipulate with and requires less computational resource. It is, however, important to perform such transformations in a principled way because any kind of dimension reduction might lead to loss of information, and it is crucial that the algorithm ...

ease progressing to end-stage renal failure. Renal fibrosis is characterized by qualitative and quantitative changes in the composition of tubular basement membranes or interstitial matrices, tubular atrophy, and the accumulation of myofibroblasts. For chronic renal disease, persistent accumulation and deposition of extracelluar matrix (ECM) which lead to widespread tissue fibrosis, are observe...

Exogenous antigens enter antigen-presenting cells through nonspecific mechanisms and are presented by the MHC II molecules. We show here that antigens chaperoned by the heat shock protein gp96 enter dendritic cells and B cells through a specific, CD91and LOX-1mediated mechanism, and are presented by MHC II molecules, in addition to MHC I molecules as previously demonstrated. Receptor utilizatio...