نتایج جستجو برای: 1 perforin proviral load

تعداد نتایج: 2872665  

Journal: :The Journal of antimicrobial chemotherapy 2014
Gabriella Rozera Isabella Abbate Emanuela Giombini Antonella Castagna Andrea De Luca Francesca Ceccherini-Silberstein Alessandro Cozzi Lepri Giovanni Cassola Carlo Torti Antonella d'Arminio Monforte Giuseppe Ippolito Maria R Capobianchi

OBJECTIVES Tropism evolution of HIV-1 quasispecies was analysed by ultra-deep pyrosequencing (UDPS) in patients on first-line combination antiretroviral therapy (cART) always suppressed or experiencing virological failure episodes. METHODS Among ICONA patients, two groups of 20 patients on cART for ≥5 years, matched for baseline viraemia and therapy duration, were analysed [Group I, patients ...

Journal: :Optics express 2007
L Wei J W Y Lit

The objective of this paper is to present a general strategy for design optimization of flattop interleavers, and dispersion compensation for the interleavers, in order to achieve superior optical performance. The interleaver is formed by two multi-cavity Gire-Tournois etalons (MC-GTE) in a Michelson Interferometer (MI). An interleaver that has m cavities in one etalon and n cavities in the oth...

Journal: :Bulletin de la Societe de pathologie exotique 2011
R Mahieux

HTLV-1 was the first human oncogenic retrovirus to be discovered. It is the etiological agent of adult T leukemia/lymphoma (ATLL) and of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM), two diseases that develop after a long latency period. Importantly, HTLV-1 does not cause ATLL through insertional mutagenesis. Apart from the gag, pro, pol and env genes, which are common to...

Journal: :Journal of immunology 2000
K J Jeffery A A Siddiqui M Bunce A L Lloyd A M Vine A D Witkover S Izumo K Usuku K I Welsh M Osame C R Bangham

The inflammatory disease human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM/TSP) occurs in only 1-2% of HTLV-I-infected individuals and is associated with a high provirus load of HTLV-I. We hypothesize that a person's risk of developing HAM/TSP depends upon the efficiency of their immune response to the virus, which differs between individuals because of polymorphism in ...

2014
Gerónimo Gutiérrez Irene Alvarez Ramiro Merlini Flavia Rondelli Karina Trono

BACKGROUND Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the main source of animal movement. In this work, we determined the proviral load and antib...

Journal: :iranian journal of immunology 0
zahra amirghofran immunology department, medical school, shiraz university of medical sciences, shiraz, iran

background: perforin is known to be important in cytolytic activity mediated by natural killer (nk) cells.   objective: to study the relationship between the efficiency of nk and lymphokine-activated killer (lak) cells activity, and the expression of perforin and hla class i molecules.   methods: lak cells were generated by in vitro culturing of human peripheral blood lymphocytes (pbls) in the ...

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