Glucocorticoids are widely used for the treatment of multiple myeloma. To investigate the direct actions of glucocorticoids on myeloma cells, we have used three cell lines of human multiple myeloma, OPM-1, OPM2, and RPMI 8226. When growth curves of these cells were examined, OPM-1 cells were resistant, while OPM-2 were sensitive to dexamethasone (DEX). In cultures of OPM-2 cells, addition of DI...

608 RISK FACTORS AND SURGICAL SOLUTIONS OF COMPLICATED LIVER HYDATID CYSTS S. Busuioc, N. Dănilă, C. Roata, O. Motaş, St. Mihalache, C. Dragomir * PhD student, “Gr. T. Popa”University of Medicine and Pharmacy, Iasi 1. Anatomy Department, “Gr. T. Popa”University of Medicine and Pharmacy, Iasi 2. First Surgical Clinic, “Gr. T. Popa”University of Medicine and Pharmacy, Iasi 3. Surgery Clinic– “St....

RU40555 is a recently available glucocorticoid receptor (GR) antagonist that differs from RU486 by a methyl radical. We have used the mouse fibroblast cell line L929 to study the in vitro effects of RU40555 on GR translocation and function and on the membrane steroid hormones transporter. The results showed that: 1) RU40555 competed for the binding of labelled dexamethasone (Dex) with a K(i) of...

We present Group Ratio Round-Robin (GR), the first proportional share scheduler that combines accurate proportional fairness scheduling behavior with O(1) scheduling overhead on both uniprocessor and multiprocessor systems. GR uses a simple grouping strategy to organize clients into groups of similar processor allocations which can be more easily scheduled. Using this strategy, GR combines the ...

Altered glucocorticoid receptor (GR) signaling is a postulated mechanism for the pathogenesis of major depression. To mimic the human situation of altered GR function claimed for depression, we generated mouse strains that underexpress or overexpress GR, but maintain the regulatory genetic context controlling the GR gene. To achieve this goal, we used the following: (1) GR-heterozygous mutant m...

Cortisol plays an important role in controlling intestinal water and ion transport in teleosts possibly through glucocorticoid receptor (GR) and/or mineralocorticoid receptor. To better understand the role of GR in the teleost intestine, in a euryhaline tilapia, Oreochromis mossambicus, we examined (1) the intestinal localizations of GR; (2) the effects of environmental salinity challenge and c...

Pulmonary glucocorticoid receptor (GR) is essential to timely preparation for the onset of breathing air at birth. We have previously used primary culture of late-gestation fetal rat lung cells to demonstrate differential regulation of GR by glucocorticoid depending on cell type. In this study, we hypothesized that the action of glucocorticoid on GR mRNA expression and protein elaboration in lu...

In the paper [Som90] p.105, Somekawa conjectures that his Milnor Kgroup K(k, G1, . . . , Gr) attached to semi-abelian varieties G1,. . . ,Gr over a field k is isomorphic to ExtrMk (Z, G1[−1] ⊗ . . . ⊗ Gr[−1]) where Mk is a certain category of motives over k. The purpose of this note is to give remarks on this conjecture, when we take Mk as Voevodsky’s category of motives DM (k) .

We have screened a panel of tetracycline (tc)-like compounds for their potential use with tc-repressor (tetR) based gene switches. The interaction between tc and tetR appears quite specific, as only tc itself and its close homologues anhydro-tc and doxycycline strongly inhibited DNA binding. However, a single tc-like compound, GR33076X, increased DNA binding of the tetR-VP16 fusion protein, bot...