Fas (CD95/Apo-1) ligand-mediated apoptosis has been recognized as an important mechanism of cell-mediated cytotoxicity and maintenance of immune homeostasis. Chronically activated T cells undergo activation-induced cell death (AICD), which depends on simultaneous Fas and Fas ligand expression. Previous reports have suggested that AICD might be linked to cell cycle progression of T cells and the...

In this paper we study the fully nonlinear free boundary problem { F (Du) = 1 a.e. in B1 ∩ Ω |Du| ≤ K a.e. in B1 \ Ω, where K > 0, and Ω is an unknown open set. Our main result is the optimal regularity for solutions to this problem: namely, we prove that W 2,n solutions are locally C inside B1. Under the extra condition that Ω ⊃ {Du 6= 0} and a uniform thickness assumption on the coincidence s...

In this article, we continue our study of the ring Baire one functions on a topological space (X,?), denoted by B1(X), and extend well known M. H. Stones?s theorem from C(X) to B1(X). Introducing structure an analogue Gelfand-Kolmogoroff is established. It observed that (X,?) may not be embedded inside This observation inspired us introduce weaker form embedding show in case X T4 space, weakly ...

Chemotherapeutic drugs ideally should take advantage of the differences between transformed and normal cells and induce apoptosis only in cancer cells. One such difference may be the overexpression of cyclin B1 protein in cancer cells, which is required for the proper progression through mitosis. Previously, we showed that treatment of human prostate cancer cells with 2-methoxyestradiol (2-ME) ...

Let β > 1, we show that if 1 has a finite greedy expansion in base β, 1=b1/β + b2/β + . . . bn/β with b1 ≥ bi ≥ 1 for i = 1, 2, . . . , n, then given an infinite coin toss, one can associate a new β-expansion of a point x in [0, ⌊β⌋ β−1 ]. We show that all such expansions can be seen as realizations of an appropriate Markov Chain. We also discuss the uniqueness of the β-expansion of 1.

Our previous study showed that the cross-linking of very without the stimulation through VLA/b1 integrin. The high late antigen (VLA)/b1 with anti-CD29 monoclonal antibody tyrosine phosphorylation pattern gradually disappeared and (MoAb), or interactions with extracellular matrix (ECM) proit was finally returned to normal tyrosine phosphorylation teins through VLA/b1, failed to induce T-cell co...

The signaling proteome of Entamoeba histolytica is made of transmembrane kinases (TMKs) that are rarely found in unicellular eukaryotes. There are 90 TMK genes reported for E. histolytica, and these have been grouped into nine distinct families based on motifs present on both extracellular and kinase domains. Of these, the B1 family was chosen for further analysis. Genomic sequencing revealed t...

Sangsree, Sakonwun, Viktor Brovkovych, Richard D. Minshall, and Randal A. Skidgel. Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists. Am J Physiol Heart Circ Physiol 284: H1959–H1968, 2003. First published March 6, 2003; 10.1152/ajpheart.00036.2003. Kininase I-type carboxypeptidases convert native kinin agonists ...

We have examined the time course and patterns of covalent aflatoxin B1:DNA adducts produced within the ribosomal RNA gene sequences isolated from the liver nuclear DNA of aflatoxin B1-treated animals. Liver nuclear DNA was initially enriched in ribosomal DNA by cesium salt density centrifugation, and incubated under alkaline conditions to stabilize bound aflatoxin B1-DNA moieties. Alkali-treate...

The bacterium Proteus mirabilis expresses a cytosolic class beta glutathione S-transferase (PmGST B1-1) that is part of a family of multifunctional detoxication enzymes. Like other cytosolic GSTs, PmGST B1-1 possesses two local structural motifs, an N-capping box and a hydrophobic staple motif, both of which are located between amino acids 151 and 156. The N-capping box consists of a reciprocal...