yψ ց m//G a/WV → t /WG where a ⊆ t is a subspace, WV ⊆ GL(a ) is a reflection group, and ψ is faithfully flat with irreducible generic fibers. Note that WV being a reflection group implies that a /WV is isomorphic to an affine space. The group WV is a very subtle invariant of V which plays a similar role as the Weyl group of the restricted root system for a symmetric space. The morphism ψ facto...

OBJECTIVES To evaluate the immunogenicity of a two-dose schedule of Baxter cell-cultured, non-adjuvanted, whole-virion H1N1 vaccine, and GlaxoSmithKline AS03(A)-adjuvanted split-virion H1N1 vaccine with respect to the EU Committee for Medicinal Products for Human Use (CHMP) and the US Food and Drug Administration (FDA) licensing criteria. DESIGN An age-stratified, randomised, observer-blind, ...

G protein-gated, inwardly rectifying K+ channels (GIRK) are effectors of G protein-coupled receptors for neurotransmitters and hormones and may play an important role in the regulation of neuronal excitability. GIRK channels may be important in neurodevelopment, as suggested by the recent finding that a point mutation in the pore region of GIRK2 (G156S) is responsible for the weaver (wv) phenot...

The weaver (wv) mutation affects the pore-forming region of the inwardly rectifying potassium channel (GIRK) leading to degeneration of cerebellar granule and midbrain dopaminergic neurons. The mutated channel (wvGIRK) loses its potassium selectivity, allowing sodium (Na+) and possibly calcium ions (Ca2+) to enter the cell. Here we performed whole cell patch-clamp recordings combined with micro...

The normal skin and other tissues of adult genetically mast cell-deficient WBB6F1-W/Wv or WCB6F1-Sl/Sld mice contain less than 1.0% the number of mast cells present in the corresponding tissues of the congenic normal (+/+) mice. We previously reported that mature dermal mast cells developed locally in the skin of W/Wv, but not Sl/Sld, mice at sites of chronic idiopathic dermatitis. We now repor...

Land use/land cover (LULC) classification is a key research field in environmental applications of remote sensing on the earth’s surface. The advent of new high resolution multispectral sensors with unique bands has provided an opportunity to map the spatial distribution of detailed LULC classes over a large fragmented area. The objectives of the present study were: (1) to map LULC classes usin...

Efficient transfer of the beta-globin gene into primitive hematopoietic progenitors was achieved with consistent and significant expression in the progeny of those cells. Retroviral vectors containing the intact genomic human beta-globin gene and the neomycin (G418)-resistance (neoR) gene were constructed. These gave titers of 10(6) or more neoR colony-forming units/ml when packaged in psi 2 ce...

Streptomyces species being the largest members of actinomycetes have been known for their metabolic capacities and form an august source of pharmacologically important compounds. The present study concentrated on in vitro evaluation of antioxidant property of n-butanol extract with antimicrobial potential from Streptomyces fradiae strain GOS1. The antioxidant activity was evaluated by total phe...

J. Skousen and J. Sencindiver, Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV 26506-6108; K. Owens, Resolve Environmental Services, Monroe, NC 28112; S. Hoover, Natural Resources Conservation Service, Middlebourne, WV 26149. Scientific contribution No. 2647 from the West Virginia Agricultural and Forestry Experiment Station, Morgantown. This research was funded by...

DC lOO%-steam plasma characteristics were investigated for the application of halogenated hydrocarbon decomposition because steam plasmas are chemically reactive. However, plasma system generally requires complex subsystems such as steam generators and cooling units. The presented steam plasma system is a portable light-weight plasma generation system that does not require any gas supply unit. ...