A 90-day oral toxicity study of γ-oryzanol, a rice-derived triterpenoid ferulate, was performed by oral gavage administration to male and female Sprague-Dawley rats at doses of 0, 1000, and 2000 mg/kg body weight/day. All rats administered γ-oryzanol survived throughout the study period. Both male and female rats showed no toxicologically significant changes of the general signs, examination fi...

This study evaluated the safety of rambutan rind extract (RRE) in male Wistar rats. While acute toxicity was evaluated by feeding the rats with single doses of RRE (1000, 2000, 3000, 4000, and 5000 mg/kg) and its sub-chronic toxicity was observed in rats orally administered with RRE (500, 1000, and 2000 mg/kg) daily for 30 days. In acute toxicity study, the LD50 was found to be greater than 500...

Background: Triple therapy with a proton pump inhibitor, c1arithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, met­ ronidazole and amoxicillin have been proposed in Maastricht 2000 as the optimal treat­ ment of Helicobacter pylori infection. We aimed to compare these two regimens in Iranian pediatric patients. Methods: A randomized clinical trial in...

background: in nature, there are herbal extracts, while capable of reducing aflatoxin b1 in agricultural product by different mechanisms, may also act as growth promoters. objectives: in this study, aqueous extract of t. daenensis was evaluated to detoxify contaminated feed with aflatoxin b1 and to determine the effect of growth promoters in japanese quail. methods: to this purpose, at 24 d of ...

Gelidium elegans extract (GEE) is derived from a red alga from the Asia-Pacific region, which has antioxidant, anti-adipogenic, and anti-hyperglycemic effects. However, detailed studies of the toxicology of GEE have not been performed. We evaluated the single oral dose toxicity of GEE in male and female Sprague-Dawley (CD) rats. GEE did not cause deaths or have toxic effects at dosages of 5000 ...

Citrus aurantifolia (Rutaceae) is a plant used in traditional medicine the treatment of inflammatory and analgesic pathologies. The objective this study was to evaluate activity aqueous extract leaves mice. phytochemical revealed flavonoids, tannins, polyphenols, coumarins, saponosides polyterpene sterols absence alkaloids. Concerning acute toxicity at single dose 2000 mg/ Kg pc orally, it that...

UP446 has been used in both joint supplements and prescription medical food. The purpose of this study was to evaluate the pharmaceutical safety of UP446 via acute and 26-week repeated oral dose toxicity study in SD rats. In acute toxicity study, UP446 was administered by oral gavage to Sprague-Dawley rats (5 males and 5 females) at a dose of 5000 mg/kg. In 26-week repeated oral dose toxicity s...