OBJECTIVE Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1beta and tumour necrosis factor (TNF). It was hypothesised that these variants could influence rheumatoid arthritis (RA) susceptibility and may interact wit...

OBJECTIVE To examine the effect of iron on the prostaglandin (PG) E2 production by human synovial fibroblasts in vitro. METHODS Human synovial fibroblasts were isolated from synovial tissue of rheumatoid arthritis (RA) and osteoarthritis (OA) patients and cultured in medium. Synovial fibroblasts were stimulated by human recombinant interleukin (IL) 1 beta (0.1-10 ng/ml) with or without ferric...

BACKGROUND Certain risk factors such as tobacco use, diabetes, genetic variations on the IL1 gene, and other inflammatory conditions are hypothesized to predict tooth loss in patients treated in a large medical center. Tooth loss trends are hypothesized to be greater in patients with more risk factors. METHODS DNA samples for 881 individuals were taken from the Dental Registry and DNA Reposit...

There is increasing evidence that the glycosaminoglycan (GAG) component of the vascular endothelium is important in regulating vascular permeability, thromboresistance and cellular interactions. We have investigated the GAG metabolism of cultured human umbilical vein endothelial cells (HUVEC) in response to a range of inflammatory stimuli. Using both chemical measurement of cellular and superna...

The present work reports for the first time the construction of a transgenic mouse strain with specific expression of Cre recombinase in the kidney proximal tubule. A Cre/loxP strategy was developed using sglt2 promoter to drive Cre recombinase expression in transgenic mice. The mouse sglt2 5' region consisting of the first exon, the first intron, and part of the second exon was cloned upstream...

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects a number of different organs and tissues. Interleukin-1 (IL1) and estrogen are considered potential elements in the pathology of SLE. Recently, the variable number of tandem repeats (VNTR) polymorphism in the IL1 receptor antagonist gene (IL1-RN) and PvuII (rs2234693) and XbaI (rs9340799) polymorphisms in the estrogen rece...

There is good evidence that the n-3 polyunsaturated fatty acids (PUFAs) in fish oil have antiinflammatory effects and reduce the pathogenesis of atherosclerosis. However, the mechanisms underlying these actions are largely unknown. This study was designed to investigate the effects of membrane incorporation of two major components of fish oil [eicosapentaenoic acid (EPA) and docosahexaenoic aci...

background and objective: host genetic factors such as cytokine gene polymorphisms as well as helicobacter pylori (h. pylori) infection have been found to be associated with gastric cancer risk . interleukin 1 is a pro-inflammatory cytokine involved in h. pylori-induced gastric inflammation. therefore, we analyzed the association between il-1β and il-1-rn polymorphisms and gastric cancer in per...

objective: asphyxia  is  a  major  cause  of  acute  mortality  and  chronic  neurologic  disability  in  neonates. we sought to  define  the  predictive  values  of  serum  concentrations  of  interleukin-1β  in  newborns  with perinatal asphyxia to see if there is a relation between interleukin-1β (il-1β) levels to the short term neurological deficit.  methods: this was a prospective (case-co...

objective(s) cytokines such as il-1β are involved in inflammatory responses. this study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain il-10 and il-1β after traumatic brain injury (tbi) in male rats. materials and methods rats were assigned into 6 groups: intact, sham, tbi, and treated rats with vehicle, celecoxib or iboprophen. cytokine concentrations wer...