Pemphigus vulgaris (PV), a severe mucocutaneous blistering disease, results from autoantibody-mediated destabilization of epidermal cell-cell adhesion. A functional risk variant at the ST18 locus was found to promote expression. Increased expression aggravate deleterious effect PV autoantibodies in part through induction p53-mediated pro-apoptotic pathways. Global RNA sequencing human keratinoc...

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We present results and first epoch parsec-scale images from a monitoring program on five γ–ray loud blazars selected on the basis of their total flux density variability. We observed 0048−097, 0235+164, 0954+658, 1510−089 and 1749+096 with the Very Long Baseline Array simultaneously at 8.4 GHz and 22 GHz. Comparison between our high quality images and previous results from the literature sugges...

INTRODUCTION The aim of this multi-center retrospective study was to quantify the changes in alveolar bone height and thickness after using two different rapid palatal expansion (RPE) activation protocols, and to determine whether a more rapid rate of expansion is likely to cause more adverse effects, such as alveolar tipping, dental tipping, fenestration and dehiscence of anchorage teeth. ME...

Objective: Much attention is paid to angiogenesis due to its mutual role in health and disease. Therefore, the effect of various chemical and physical agents on inhibition of this process has been recently studied. This study was conducted to investigate the synergic effect of glycyrrhizic acid and electromagnetic field on angiogenesis. Materials and Methods: In this experimental study, 44 Ross...

BACKGROUND We have previously shown that angiotensin II type 2 receptor (AT(2)R) stimulation causes endothelium-dependent vasodilation that does not desensitize after chronic angiotensin II type 1 receptor (AT1R) blockade, suggesting a role for AT2R in antihypertensive treatment. METHODS AND RESULTS We recorded mean arterial pressure (MAP) and investigated AT2R by Western blot analysis, immun...

BACKGROUND The peritoneal spread of cancer is a well-known entity carrying a dismal prognosis. A new therapeutic approach is the combination of cytoreduction with heated intraperitoneal chemotherapy (HIPC). The risk of an intra-abdominal anastomosis in the presence of such chemotherapy is recognized clinically but the experimental data on the subject are lacking. The aim of this study is to exa...

17.9 mm Hg. In patients with BMIs lower than 30 kg/m2, systolic BP was reduced by 30.6 mm Hg and diastolic BP was reduced by 20.6 mm Hg. The percentages of patients receiving combination therapy who achieved BP goals at the eighth week also tended to be greater if the BMI was below 30 kg/m2 (41%–55%) than if the BMI was higher (28%–52%). “Olmesartan should reduce the edema associated with amlod...

Equations for calculating evapotranspiration in technical soils show great differences regarding their results. Causes are the different climatic conditions and vegetation specifics during development. Every equation of only delivers 100% correct results if it is used under same condition as was developed in. To determine evapotranspiration, loss weight plants measured a test series on load cel...

Low-dose thiazide-type diuretics are recommended as initial therapy for most hypertensive patients. Chlorthalidone has significantly reduced stroke and cardiovascular end points in several landmark trials; however, hydrochlorothiazide remains favored in practice. Most clinicians assume that the drugs are interchangeable, but their antihypertensive effects at lower doses have not been directly c...