نتایج جستجو برای: 091

تعداد نتایج: 509  

Journal: :Human Reproduction 2023

Abstract The impact of endocrine disruptors on early pregnancy and clinical outcomes in IVF Moncef Benkhalifa (1,2,3), Debbie Montjean (2), Hafida Corsi-Cauet (3), Henri Copin (1,3), Véronique Bach Pierre Miron Rosalie Cabry (1,3) (1) Reproductive Medicine Genetics, University Hospital & School Medicine. Picardie Jules Verne. Amiens France (2) ART Centers. Laval Brossard. Fertilys Internati...

Journal: :Journal of Investigative Dermatology 2022

Hidradenitis suppurativa (HS) is characterized by inflammatory nodules, abscesses and fistulas. Severity can be assessed several scores requiring detailed, time-consuming error-prone lesion counts. This study aimed to investigate automated HS-severity classification from clinical images. 777 distinct images 149 patients were taken using smartphones. Images ambient-light size-controlled the Scar...

2017
Hai-Tsang Huang Hyuk-Soo Seo Tinghu Zhang Yubao Wang Baishan Jiang Qing Li Dennis L Buckley Behnam Nabet Justin M Roberts Joshiawa Paulk Shiva Dastjerdi Georg E Winter Hilary McLauchlan Jennifer Moran James E Bradner Michael J Eck Sirano Dhe-Paganon Jean J Zhao Nathanael S Gray

Thorough preclinical target validation is essential for the success of drug discovery efforts. In this study, we combined chemical and genetic perturbants, including the development of a novel selective maternal embryonic leucine zipper kinase (MELK) inhibitor HTH-01-091, CRISPR/Cas9-mediated MELK knockout, a novel chemical-induced protein degradation strategy, RNA interference and CRISPR inter...

2017

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2013
Jonathan Sprinkle J. Sprinkle

This final report provides the results of the Modeling of Embedded Human Systems (MEHS) project, Award #FA9550-091-0519. The goal of the work was a new approach to modeling embedded human systems; that is, systems where components are both human and computational. These systems are unique since the differences in time for a computational controller, as opposed to a human-centric controller, wil...

2016

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2015

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2015

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