The potential metabolic drug interactions between TNP-470, a potent inhibitor of angiogenesis, and several commonly used anticancer agents, such as cyclophosphamide, taxol, and minocycline, were investigated in vitro using primary cultured hepatocytes and microsomes of rhesus monkeys. After incubation of hepatocytes with 5 microM [3H]TNP-470, rapid and extensive formation of six metabolites was...

X k=1 z 0k A0;k(z M)Mi01(z M): (41) This formula makes transparent exactly what happens in a recursive computation of the correlation functions. At every stage i, we have the Z-transform at points M 0i n of the appropriate function. In going to the (i + 1)st stage, the rst term Mi01(z M) ensures that values at the previous stage are retained at the even points, while the second term interpolate...

N 27 27 – Age [years; months] (age range) 10;5±2;7 (6;6–16;4) 11;0±1;11 (8;5–17;0) T=0.81; df=52; P=.42 Sex (f/m) 8/19 7/20 χ=0.09; df=1; P=.76 IQ 80±17 107±12 T=6.55; df=52; Pb .01 CBCL (total t-score) 64.08±9.05 (n=25) 48.67±5.38 T=−7.54; df=50; Pb .01 General ADHD symptoms 1.00±0.51 (n=24) 0.30±0.23 (n=26) T=−6.37; df=48; Pb .01 Depressive symptoms 48.96±9.95 (n=26) 42.89±8.00 T=−2.45; df=51...

George M. Bollas, Simira A. Papadopoulou, Angelos A. Lappas, Spyros S. Voutetakis, Panos Seferlis, and Iacovos A. Vasalos 1 Chemical Process Engineering Research Institute (CPERI), Centre for Research and Technology Hellas (CERTH), 6th km Charilaou–Thermi Rd, PO Box 361, Thessaloniki, GR-570 01, Greece, 2 Department of Automation, Alexander Technological Educational Institute (ATEI) of Thessalo...

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Our purpose was to demonstrate that 30-s tethered swimming test can be a useful tool to estimate swimming performance in short distance freestyle events. Thirteen high level adolescent swimmers (7 male and 6 female of 16.6 ± 1.0 and 15.8 ± 0.8 years old) performed a 30-s maximum effort in front crawl tethered swimming. Afterward, subjects completed 50-m and 100-m freestyle events at the Nationa...

The objective of this study was to analyse selected kinematic parameters (time of flying, in-run velocity, take-off velocity, out-run velocity, height of flying at 17 m, height of flying at 75 m, height of flying at 120 m, aerodynamic index at 17 m, aerodynamic index at 75 m, aerodynamic index at 120 m) of the best world-class ski jumpers participating in the two final individual competitions (...

Spectroscopy is one of the most important tools that an astronomer has for studying the universe. This chapter begins by discussing the basics, including the different types of optical spectrographs, with extension to the ultraviolet and the near-infrared. Emphasis is given to the fundamentals of how spectrographs are used, and the trade-offs involved in designing an observational experiment. I...