Lindh, M. 2017. Computational Modelling in Drug Discovery. Application of StructureBased Drug Design, Conformal Prediction and Evaluation of Virtual Screening. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 235. 47 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0049-8. Structure-based drug design and virtual screening are areas of computation...

BACKGROUND Social factors in the patient macroenvironment have been shown to influence molecular events in the tumor microenvironment and thereby influence cancer progression. However, biomarkers providing a window into the longitudinal effects of biobehavioral factors on tumor biology over time are lacking. Exosome analysis is a novel strategy for in vivo monitoring of dynamic changes in tumor...

OBJECTIVES The purpose of this study was to compare the joint space width between one-leg and both-legs standing radiographs in order to diagnose a primary osteoarthritis of the knee. METHODS Digital radiographs of 100 medial osteoarthritic knees in 50 patients were performed. The patients had undergone one-leg standing anteroposterior (AP) views by standing on the affected leg while a both-l...

0049-089X/$ see front matter 2012 Elsevier Inc http://dx.doi.org/10.1016/j.ssresearch.2012.03.006 ⇑ Fax: +1 225 578 2697. E-mail address: [email protected] 1 See Table 2; McLanahan and Sandefur (1994) an 2 McLanahan and Sandefur (1994), p. 1 (emphasis 3 Waite (1995). 4 Gaudino et al. (1999) and Siegel et al. (1996). 5 Wilcox et al. (2005, p. 28) and Cutler et al. (2000 6 Bachman et al. (1997), Fle...

Auditory-perceptual evaluation is the most commonly used clinical voice assessment method, and is often considered a gold standard for documentation of voice disorders. This view has arisen for many reasons, including the fact that voice quality is perceptual in nature and that the perceptual characteristics of voice have greater intuitive meaning and shared reality among listeners than do many...

Embodied cognition suggests that complex cognitive traits can only arise when agents have a body situated in the world. The aspects of embodiment and situatedness are being discussed here from the perspective of linear systems theory. This perspective treats bodies as dynamic, temporally variable entities, which can be extended (or curtailed) at their boundaries. We show how acting agents can, ...

PURPOSE To evaluate the retention of bone around implants placed immediately following tooth extraction and used to support dental prostheses. MATERIALS AND METHODS Patients from a previous study of implants placed immediately following tooth extraction were recalled to the original practice to obtain dental radiographs, which were then used to compare bone levels after 1 to 22 years of clini...

In the last few years, galaxies at redshifts up to z ∼ 1 have become accessible for medium–resolved spectroscopy thanks to the new generation of 10m-class telescopes. With kinematic and photometric information on spiral galaxies in this regime, well–known scaling relations like the Tully–Fisher relation (TFR) can be studied over half a Hubble time. By comparison to local samples, these studies ...

Changes in agricultural land use have important implications for environmental services. Previous studies of agricultural land use futures have been published indicating large uncertainty 10 due to different model assumptions and methodologies. In this paper we present a first comprehensive comparison of global agro-economic models that have harmonized drivers of population, GDP and biophysical...

The welfare reform debate centers on whether the best strategy to reduce poverty is to raise work participation among low-income women or to promote marriage. Using the 1992–2001 demographic supplements of the Current Population Survey, we track child poverty rates before and after passage of the 1996 Personal Responsibility and Work Opportunity Reconciliation Act. We find that increasing mater...