INTRODUCTION In this study we investigated the effect of 12 weeks of cycle ergometer training in patients with spinal muscular atrophy type III (SMA III), a hereditary motor neuron disease with progressive muscle weakness and atrophy. METHODS Six SMA III patients and 9 healthy subjects completed a 12-week training program, performing 42 30-minute sessions exercising at 65-70% of maximal oxyge...

The adaptive response of maximal aerobic power (VO2max) to endurance exercise training was compared in 53 men and 57 women, aged 60-71 yr. The subjects were healthy and had been sedentary for at least 2 yr. Pretraining VO2max was measured during graded treadmill walking on two occasions. These values were reproducible (24.4 +/- 4.7 vs. 24.4 +/- 4.6 (SD) ml.min-l.kg-1; r = 0.96). Subjects traine...

The fuel selection of muscle fibres at rest is dependent on substrate availability. Increased lipid availability results in an increase citrate concentration with inhibition of glycolysis. Fat utilization also increases the concentration ratio acetyl-CoA:CoASH, with inhibition of PDH transformation to the active form. The result is an inhibition of carbohydrate utilization in conformity with th...

Running economy (RE) at an intensity above the lactate threshold (LT) is reported to be the most important aerobic capacity for estimating 1,500-m running performance. The reason that the RE at intensity better reflects the energy metabolism during a 1,500-m run, is that it is performed above the LT intensity running. This study clarified the relationship between an 800-m run, which is performe...

BACKGROUND The purpose of this study was to examine whether very short duration, very high intensity sprint interval training (SIT) leads to loss of body fat mass in association with improvements to VO2max and fatty acid oxidation, and to assess the extent of sex dimorphism in these physiological responses. METHODS A total of 24 men and 17 women (mean (SEM) age: 39 (±2) years; body mass index...

Methods Twenty-five well-trained recreational athletes (mean ± SD age = 21 ± 2 yrs; stature = 172 ± 9 cm; body mass = 66 ± 12 kg, VO2max = 48 ± 9 ml·kg-1·min-1, percent body fat = 19 ± 7%) were assigned to either the active supplement (n = 12) or placebo (PL, n = 11) group. The active supplement (Game Time®, GT, Corr-Jensen Laboratories Inc., Aurora, CO) was 18 g of powder, 40 kcals, and consis...

Exercise intolerance is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still unsettled whether exercise training is safe and beneficial for patients with MM. To address this, we studied the effect of 12 weeks cycle training on exercise capacity, quality of life and underlying molecular and cellular events in five patients with single large-scale deletions, one with ...