Isolation of CYP72A154, a gene involved in glycyrrhizin biosynthesis pathway, Glycyrrhiza glabra L. (Iranian licorice)

licorice is obtained from glycyrrhiza glabra (g. glabra) in iran. glycyrrhizin is the main constituent of g. glabra and has several pharmacological effects. it is hydrolyzed to glycyrrhetic acid (ga) in the intestine after oral administration. in this study, a novel hplc method was used to determine the concentration of ga in rat plasma after oral administration of licorice aqueous extract. the...

Primary dysmenorrhea is a common gynecological disorder in women of reproductive age. Despite the effective treatments such as nonsteroidal anti-inflammatory drugs and oral contraceptives, researchers have always been looking for alternative drugs due to the adverse effects and limited efficacy of conventional medications. Glycyrrhiza glabra L. (G. glabra), commonly known as Licorice, has been ...

Tuberculosis (TB) remains a highly significant infection of microbial origin causing death of human in developing countries. The anti-tubercular drugs are less effective because of the emergence of multi-drug resistant strains and ineffective to extensively drug resistant strains of Mycobacterium tuberculosis. Plants are being an alternative source of antimicrobial compounds; the aim of this st...

Sarcandra glabra was a renowned herb traditionally used as herbal tea or food supplement to enhance mental efficiency and to recover from stress or fatigue in China. We investigated the effects of Sarcandra glabra extract (SGE), with chemical composition clearly showed by HPLC fingerprint as quality control, on immunologic response including natural killer (NK) cell activity and its antioxidati...

The association of chronic inflammation with development of human cancer is well recognized. There are number of reports of involvement of inflammatory process in the initiation and progress of cancer. The search for selective inhibitors of Cyclooxygenase-2 isoenzymes and that too from natural origin is considerably important. Rubia cordifolia L. and Glycyrrhiza glabra L. find an important plac...

Assessment report on Glycyrrhiza glabra L. and/or Glycyrrhiza inflata Bat. and/or Glycyrrhiza uralensis Fisch., radix Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use) Final Herbal substance(s) (binomial scientific name of the plant, including plant part) Glycyrrhiza glabra L. and/or of Glycyrrhiza inflata Bat. and/or Glycyrrhiza uralensis...