Four new species, Macrocarpaea dies-viridis (Ecuador), M. luctans (Ecuador, Peru), M. lucubrans (Panama), and M. opulenta (Ecuador), and two natural hybrids, M. × acuminata (Costa Rica) and M. × mattii (Ecuador), are described. Macrocarpaea × acuminata Weaver (pro sp.) is recognized as a natural hybrid between M. subcaudata and M. valerii, rather than as a distinct species, and M. × mattii is d...