The association of p120-catenin (p120) with the juxtamembrane domain (JMD) of vascular endothelial (VE)-cadherin is required to maintain VE-cadherin levels and transendothelial resistance (TEER) of endothelial cell monolayers. To distinguish whether decreased TEER was due to a loss of p120 and not to the decrease in VE-cadherin, we established a system in which p120 was depleted by short hairpi...

Vascular endothelial-cadherin (VE-cadherin) plays a key role in angiogenesis and in vascular permeability. The regulation of its biological activity may be a central mechanism in normal or pathological angiogenesis. VE-cadherin has been shown to be phosphorylated on tyrosine in vitro under various conditions, including stimulation by VEGF. In the present study, we addressed the question of the ...

STUDY DESIGN A prospective study. OBJECTIVE The aim of this study was to analyze the proximal thoracic (PT) flexibility and its compensatory ability above the "potential UIV." SUMMARY OF BACKGROUND DATA Shoulder and neck imbalance can be caused by overcorrection of the main thoracic (MT) curve due to inability of PT segment to compensate. METHODS Cervical supine side bending (CSB) radiogr...

Vascular endothelial-cadherin (VE-cadherin) plays a key role in angiogenesis and in vascular permeability. The regulation of its biological activity may be a central mechanism in normal or pathological angiogenesis. VE-cadherin has been shown to be phosphorylated on tyrosine in vitro under various conditions, including stimulation by VEGF. In the present study, we addressed the question of the ...

Amaç: Stres ve anksiyete baş ağrılarının en sık tetikleyicileridir. Kişilik özellikleri ve başa çıkma yöntemleri bireylerin strese verdiği yanıtı etkiler. Yapılan çalışmalarda kaygılı ve depresif kişilik özelliklerinin başağrısına yatkınlık oluşturabileceğini, başağrısı olan hastaların işlevsel olmayan başa çıkma yöntemlerini daha sık kullandıklarını göstermiştir. Bu çalışmada migren ve gerilim...

Maintenance and remodeling of endothelial cell junctions critically depend on the VE-cadherin/catenin complex and its interaction with the actin filament cytoskeleton. Here we demonstrate that local lack of vascular endothelial (VE)-cadherin at established cell junctions causes actin-driven and actin-related protein 2/3 complex (ARP2/3)-controlled lamellipodia to appear intermittently at those ...

DOI: 10.4328/JCAM.4959 Received: 22.02.2017 Accepted: 11.03.2017 Printed: 01.04.2017 J Clin Anal Med 2017;8(suppl 2): 109-13 Corresponding Author: Şule Çolakoğlu, Başkent Üniversitesi, Adana Dr. Turgut Noyan Uygulama ve Araştırma Merkezi, Yüreğir, Adana, Türkiye. GSM: +905332394006 E-Mail: [email protected] Öz Human papillomavirus (HPV) prevelansını ve genotip dağılımının değerlendirilmes...

Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercetin (Q) in 65 F-344 rats (n=13 per group) randomly assigned to the following vitamin E (VE)-replet...

The heterotrimeric G protein Gα13 transduces signals from G protein-coupled receptors (GPCRs) to induce cell spreading, differentiation, migration, and cell polarity. Here, we describe a novel GPCR-independent function of Gα13 in regulating the stability of endothelial cell adherens junctions (AJs). We observed that the oxidant H2O2, which is released in response to multiple proinflammatory med...

Özet. Başarısız giden birçok proje, hatalı yönetilen süreçler, ürünlerin ve projelerin zamanında teslim edilememesi, maliyetlerde oluşan aşırı artışlar yazılım mühendisliğinde risk yönetiminin önemini günden güne arttırmaktadır. Özellikle risklerin düzgün bir şekilde ele alınamaması, projeler arası risk türlerinin ve gruplarının farklılaşması, şirket/kurum içi yapılan risk yönetimi ve risk anal...