Neuropeptide Y (NPY) coexists with vasopressin or oxytocin in magnocellular neurons of the hypothalamo-neurohypophysial tract. Using quantitative in situ hybridization histochemistry and immunohistochemistry, we have studied the effects of adrenalectomy and chronic osmotic stimulation, either alone or in combination, on NPY mRNA expression and NPY immunoreactivity in magnocellular neurons of th...

Neuropeptide Y (NPY) can cause diuresis, natriuresis, and calciuresis in rats independently of the pressure-natriuresis mechanism (A. Bischoff and M. C. Michel. Pflügers Arch. 435: 443-453, 1998). Because this is seen in systemic but not intrarenal NPY infusion, we have investigated the possible mediator of tubular NPY effects in anesthetized rats. In the present study, infusion of NPY (2 μg ⋅ ...

Increased neuropeptide Y (NPY) gene expression in the dorsomedial hypothalamus (DMH) has been shown to cause hyperphagia, but the pathway underlying this effect remains less clear. Hypothalamic neural systems play a key role in the control of food intake, in part, by modulating the effects of meal-related signals, such as cholecystokinin (CCK). An increase in DMH NPY gene expression decreases C...

Neuropeptide Y (NPY), a 36-aa peptide, is widely distributed in the brain and peripheral tissues. Whereas physiological roles of NPY as a hormoneneurotransmitter have been well studied, little is known about its other peripheral functions. Here, we report that NPY acts as a potent angiogenic factor in vivo using the mouse corneal micropocket and the chick chorioallantoic membrane (CAM) assays. ...

Neuropeptide Y (NPY) plays an important role in pain modulation at different levels in the central nervous system. In the brain, NPY and NPY receptors distribute abundantly in the arcuate nucleus of hypothalamus (ARC), a structure involved in pain processing. The present study was undertaken to investigate the role of NPY in nociceptive modulation in the ARC of intact rats and rats with carrage...

Previous studies showed that neuropeptide Y (NPY) inhibited hippocampal epileptiform activity and that endogenous NPY might have neuroprotective effects. Therefore, in the present study, the effect of NPY microinjected intrahippocampally on the kainate-induced lesion and changes in NPY immunoreactivity (-IR) were investigated in rat hippocampus. Male Wistar rats, chronically cannulated, were un...

OBJECTIVE Attempts to restore blood flow through atherosclerotic vessels by angioplasty often result in restenosis. Because the role of nerves in this process is unclear, we investigated whether neuropeptide Y (NPY), a sympathetic cotransmitter with vascular mitogenic activities, contributes to postangioplasty restenosis. METHODS AND RESULTS Carotid artery balloon angioplasty upregulated vasc...

The impact of obesity upon bone metabolism is controversial since both beneficial or harmful effects have been reported. Bone remodeling modulated by the central nervous system through cytokines, hormones and neuromodulators. present study aimed to evaluate evoked bilateral retroperitoneal white adipose tissue (rWAT) denervation (Dnx) mineral in an experimental model rats. Male Wistar rats were...

Objective: Appetite regulation has a great impact on energy homeostasis. This study aimed to compare the response agouti-related protein (AGRP) and neuropeptide Y (NPY) to a single high intensity interval training (HIIT) in obese and underweight men. Materials and Methods: This semi-experimental research conducted on 40 obese and underweight men who were divided into four groups including expe...

To investigate the release of neuropeptide Y (NPY) from the pheochromocytomas, we studied the relationship between the plasma and tumor tissue immunoreactive (IR) NPY concentrations in 13 patients with pheochromocytoma and measured the IR-NPY concentration in plasma samples obtained by catheter from several veins (jugular veins, superior vena cava, renal veins, adrenal veins and inferior vena c...