هدف: از چالش­های عمده بشریت افزایش افسردگی و اختلال عملکرد جنسی ناشی داروهای ضدافسردگی است. با توجه به نقش سلول­های سرتولی در اسپرماتوژنز، پژوهش حاضر، اثر داروی دولوکستین را بر زنده­مانی، آپوپتوزیس بیان ژن­های Bax و­ (Connexin 43) Cx43 بررسی کرده مواد روش‌‌ها: TM4 محیط DMEM/F12 حاوی %5/2 FBS، 5% سرم اسب %1 پنی سیلین-استرپتومایسین کشت شدند. دوزهای 30،60، 15، 5/7، 75/3 میکرو­گرم/ میلی­لیتر زمان­ه...

On Saturday July 10, 1976, it was a warm spring day filled with blue skies and normalcy. With children playing outside under the sun-kissed rays and others enjoying lunch outdoors, all were oblivious to one of the biggest man-made chemical disasters that was about to take place. What was a seemingly picturesque afternoon was soon to be history due to the foreboding thick, whitish cloud overhead...

This paper proposes a new dynamic multi-objective optimization algorithm by integrating fitting-based prediction (FBP) mechanism with regularity model-based estimation of distribution (RM-MEDA) for in changing environments. The prediction-based reaction aims to generate high-quality population when changes occur, which includes three subpopulations tracking the moving Pareto-optimal set effecti...

Pelaksanaan pembelajaran IPS yang monoton serta minimnya penggunaan meda dan sumber belajar menyebabkan munculnya sikap disrutif siswa. Penelitian ini bertujuan mendeskripsikan inovasi melalui Technological Pedagogical Content Knowledge (TPACK). merupakan penelitian kualitatif dengan menggunakan metode lapangan (field research) fokus pada (TPACK) di MI Muhammadiyah Karanglo Kecamatan Cilongok K...

Disclosure of potential conflict of interest: L. Cox is a consultant for Genentech/Novartis, Hollister-Stier, and Stallergenes; is a speaker for Novartis; has received research support from Stallergenes; is on the Board of Directors for the American Board of Allergy and Immunology; and is on the US Food and Drug Administration (FDA)’s Allergenic Product Advisory Committee. H. Nelson is a consul...

Abstract Identifying, evaluating, and prioritizing freshwater systems for conservation is a persistent challenge managers tasked with recovery of native fishes. We used historical records from the Gila River basin, national hydrography data set, Random Forest modeling to predict probability Spikedace Meda fulgida Loach Minnow Rhinichthys cobitis occurrence throughout their range in basin. Model...