نتایج جستجو برای: ژن catsper

تعداد نتایج: 15936  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Huayu Qi Magdalene M Moran Betsy Navarro Jayhong A Chong Grigory Krapivinsky Luba Krapivinsky Yuriy Kirichok I Scott Ramsey Timothy A Quill David E Clapham

Mammalian spermatozoa become motile at ejaculation, but before they can fertilize the egg, they must acquire more thrust to penetrate the cumulus and zona pellucida. The forceful asymmetric motion of hyperactivated spermatozoa requires Ca2+ entry into the sperm tail by an alkalinization-activated voltage-sensitive Ca2+-selective current (ICatSper). Hyperactivation requires CatSper1 and CatSper2...

2015
Juan I. Ernesto Mariana Weigel Muñoz María A. Battistone Gustavo Vasen Pablo Martínez-López Gerardo Orta Dulce Figueiras-Fierro José L. De la Vega-Beltran Ignacio A. Moreno Héctor A. Guidobaldi Laura Giojalas Alberto Darszon Débora J. Cohen Patricia S. Cuasnicú

Ca(2+)-dependent mechanisms are critical for successful completion of fertilization. Here, we demonstrate that CRISP1, a sperm protein involved in mammalian fertilization, is also present in the female gamete and capable of modulating key sperm Ca(2+) channels. Specifically, we show that CRISP1 is expressed by the cumulus cells that surround the egg and that fertilization of cumulus-oocyte comp...

2013
Nadja Mannowetz Natasha M Naidoo Seung-A Sara Choo James F Smith Polina V Lishko

Mammalian spermatozoa gain competence to fertilize an oocyte as they travel through the female reproductive tract. This process is accompanied by an elevation of sperm intracellular calcium and a membrane hyperpolarization. The latter is evoked by K(+) efflux; however, the molecular identity of the potassium channel of human spermatozoa (hKSper) is unknown. Here, we characterize hKSper, reporti...

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