We describe a challenging case of patient with metallo-beta-lactamase-producing Pseudomonas aeruginosa sternal osteomyelitis following aortic valve replacement biological prosthesis. The strain exhibited multidrug-resistance phenotype carrying the blaVIM-1 gene and belonged to high-risk clone sequence type ST235. was successfully treated surgical debridement plus antibiotic therapy ceftazidime/...

Dear Sir, Carbapenems are one of the most critically important antimicrobials and are considered as last-choice drugs in clinical settings. However, the emergence and dissemination of Enterobacteriaceae carrying acquired metallo-β-lactamases (MBLs) is being increasingly reported throughout the world, presenting a serious threat to the effectiveness of carbapenem treatment [1]. Acquired MBLs, su...

In this brief communication we describe the occurrence of a KPC-producing Serratia marcescens isolate in a home-care patient from Recife, Brazil. The blaKPC, blaSPM, blaIMP, blaVIM, blaOXA, blaCTX-M, blaSHV, blaTEM and blaGES genes were investigated by Polymerase Chain Reaction (PCR) and DNA sequencing. The isolate was positive for blaKPC-2 and blaTEM-1 and was resistant to aztreonam, cefepime,...

The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor ...

Background: Acinetobacter baumannii has emerged as a critical pathogen with high morbidity and mortality in long-term hospitalized patients who stay intensive care units. Carbapenemases integrons are two DNA elements that contribute to the emergence of multidrug-resistant (MDR) A. baumannii. Objectives: The current study aimed at characterization molecular detection class 1, 2, 3 among carbapen...

OBJECTIVES A growing incidence of pathogens producing carbapenemases has been observed in many countries including Bangladesh. The present study was carried out to determine the presence of carbapenemase producers among uropathogens. MATERIALS AND METHODS A total of 138 Gram-negative uropathogens were isolated and identified by conventional methods and were screened for carbapenemase producti...

We evaluated the investigational use only (IUO) version of the rapid Verigene Gram-negative blood culture test (BC-GN), a microarray that detects 9 genus/species targets (Acinetobacter spp., Citrobacter spp., Enterobacter spp., Escherichia coli/Shigella spp., Klebsiella oxytoca, Klebsiella pneumoniae, Proteus spp., Pseudomonas aeruginosa, and Serratia marcescens) and 6 antimicrobial resistance ...