The anterior cingulate cortex (ACC) is critically involved in processing the affective component of pain sensation. Visceral hypersensitivity is a characteristic of irritable bowel syndrome. Electrophysiological activity of the ACC with regard to visceral sensitization has not been characterized. Single ACC neuronal activities in response to colorectal distension (CRD) were recorded in control,...

Acetyl-CoA carboxylase (ACC), the first committed enzyme in fatty acid (FA) synthesis, is regulated by phosphorylation/dephosphorylation, transcription, and an unusual mechanism of protein polymerization. Polymerization of ACC increases enzymatic activity and is induced in vitro by supraphysiological concentrations of citrate (> 5 mM). Here, we show that MIG12, a 22 kDa cytosolic protein of pre...

Acetyl-CoA carboxylase (ACC) catalyzes the formation of malonyl-CoA, a precursor in the biosynthesis of long-chain fatty acids, which have been implicated in physiological insulin secretion. The catalytic function of ACC is regulated by phosphorylation (inactive)-dephosphorylation (active). In this study we investigated whether similar regulatory mechanisms exist for ACC in the pancreatic islet...

Chen J, Jeppesen PB, Nordentoft I, Hermansen K. Stevioside improves pancreatic -cell function during glucotoxicity via regulation of acetyl-CoA carboxylase. Am J Physiol Endocrinol Metab 292: E1906 –E1916, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00356.2006.—Chronic hyperglycemia is detrimental to pancreatic -cells, causing impaired insulin secretion and -cell turnover. The char...

Adaptive Cruise Control (ACC) is assumed to have a potential to improve quality-of-service and safety and to reduce the environmental impact of the road traffic system. This paper use vehicle trajectories from traffic simulation to study impacts of ACC on vehicle acceleration and deceleration rates. The analysis is based on traffic simulations with car-following models including ACC functionali...