نتایج جستجو برای: چارچوب gof
تعداد نتایج: 18532 فیلتر نتایج به سال:
The main tumor suppressor function of p53 as a "guardian of the genome" is to respond to cellular stress by transcriptional activation of apoptosis, growth arrest, or senescence in damaged cells. Not surprisingly, mutations in the p53 gene are the most frequent genetic alteration in human cancers. Importantly, mutant p53 (mutp53) proteins not only lose their wild-type tumor suppressor activity ...
the study of the potntial for using leucaena leucocephala or manihot esculentafor supplementing feeding of west african dwarf goats were carried out from november 2003 to january 2004 inthe experimental farm of the universityof dschang. twenty four west african dwarf goats, were divided in three groups of eight animals, each one 12 months old with average weight of 13.1±4.4 kg, were used in thi...
Chronic mucocutaneous candidiasis (CMC) is a primary immunodeficiency characterized by persistent or recurrent skin and mucosal surface infections with Candida species. Different gene mutations leading to CMC have been identified. These include various heterozygous gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 (STAT1) that are not only associated with in...
Goodness-of-Fit (GoF) based spectrum sensing of orthogonal frequency-division multiplexing (OFDM) signals is investigated in this paper. To this end, some novel local sensing methods based on Shapiro-Wilk (SW), Shapiro-Francia (SF), and Jarque-Bera (JB) tests are first studied. In essence, a new threshold selection technique is proposed for SF and SW tests. Then, three studied methods are appli...
SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates melanoma formation. However, the mechanism by which SETDB1 regulates tumorigenesis remains unknown. Here we report the molecular interplay between SETDB1 and the well-known hotspot gain-of-function (GOF) TP53 R249S mutation. We show that ...
Joint representation of color-based features for multiple images or a video segment is an important task for visual information management systems. Generally, a key-frame or key-image is selected from such a group, and the color-related features of the entire collection are represented with those of the chosen sample. Such methods are highly dependent on the quality of the representative sample...
Mutant p53 (mtp53) gain of function (GOF) contributes to various aspects of tumor progression including cancer stem cell (CSC) property acquisition. A key factor of GOF is stabilization and accumulation of mtp53. However, the precise molecular mechanism of the mtp53 oncogenic activity remains unclear. Here, we show that ribophorin II (RPN2) regulates CSC properties through the stabilization of ...
This document reports a simple and effective method to determine global camera motion using raw MPEG-1 motion vectors information obtained straight from the real MPEG-1 streams such as that of the new HITACHI MP-EG1A digital camcorder. The simple approach we have experimented with robustly fits a global affine optic flow model to the motion vectors. Other more robust methods are also proposed. ...
Rozo and Gronvall, in “The Reemergent 1977 H1N1 Strain and the Gain-of-Function Debate” (1), confirmed the laboratory origin of the 1977 influenza pandemic and judged it was unintentional, but they concluded that its “relevance to GoF research is greatly diminished if the 1977 epidemic was the result of a vaccine trial or vaccine development gone awry; these are both more plausible explanations...
Abstract We propose a spatiotemporal point process model that enhances the classical Epidemic-Type Aftershock Sequence (ETAS) model. This is achieved with introduction of renewal main-shock arrival and we call this extension ETAS (RETAS) modification similar in spirit to Hawkes (RHawkes) but conditional intensity supports spatial component. It empowers reset upon main-shocks. allows for heavier...
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