The HIV gp41 protein catalyzes fusion between viral and target cell membranes. Although the ~20-residue N-terminal fusion peptide (FP) region is critical for fusion, the structure of this region is not well characterized in large gp41 constructs that model the gp41 state at different times during fusion. This paper describes solid-state NMR (SSNMR) studies of FP structure in a membrane-associat...

The Arctic sea ice cover has decreased strongly in extent, thickness, volume and age in recent decades. The melt season presents a significant challenge for sea ice forecasting due to uncertainty associated with the role of surface melt ponds in ice decay at regional scales. This study quantifies the relationships of spring melt pond fraction (fp) with both winter sea ice roughness and thicknes...

OBJECTIVES To compare the efficacies of medium-dose fluticasone propionate (FP), medium-dose triamcinolone acetonide (TAA), and combined low-dose FP plus salmeterol (SL). DESIGN Randomized, double-blind, triple-dummy, multicenter, 12-week clinical trial. SETTING Allergy/respiratory care clinics. PATIENTS Six hundred eighty patients with asthma previously uncontrolled with low-dose inhaled...

We assessed knowledge, attitude, and provision of recommended fall prevention (FP) practices by employees of senior-serving organization and participation in FP practices by at-risk elders. The Washington State Department of Health administered structured telephone surveys to 50 employees and 101 elders in Washington State. Only 38% of employees felt "very knowledgeable" about FP, and a majorit...

is one of the most familiar, and most studied, families of elliptic curves, often used for testing conjectures and for illustrating theorems. When we became interested in the Lang-Trotter conjecture [L-T, page 33] in the function field case, cf. [Ka-LTR], we turned to this family to do some computer experiments. This paper reports on an empirical discovery made in the course of those experiment...

A cDNA clone coding for a functional human prostanoid FP receptor has been isolated from a uterus cDNA library. The human FP receptor consists of 359 amino acid residues with a predicted molecular mass of 40,060, and has the seven putative transmembrane domains characteristic of G-protein-coupled receptors. Challenge of Xenopus oocytes expressing the FP receptor with 10 nM of either prostagland...

24 Background: Combination inhaled therapy with long-acting β2-agonist (LABA) and corticosteroid 25 is beneficial in treating asthma and chronic obstructive pulmonary disease (COPD). 26 Objective: In asthma, LABAs enhance glucocorticoid receptor (GR) nuclear translocation in the 27 presence of corticosteroids. Whether this biological mechanism occurs in COPD, a relatively 28 corticosteroid-resi...

PURPOSE This research evaluated initial treatment of deep dental caries with caries control (CC) procedure and the effect of other factors on the success of indirect pulp therapy (IPT) and formocresol pulpotomy (FP). METHODS Retrospective chart audits were performed on 226 primary molars with deep caries approaching the pulp that were treated using IPT and FP. Mean follow-up was 3.4 years. CC...

OBJECTIVES R-flurbiprofen (R-FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β-amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed a challenge to its further development for AD treatment. In this study, we investigated the potential of serum albumin as nanoparticulate carrier...