Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are two common problems in aging men, and pose increasing concerns in health care and social burden as the population ages. In the United States, PCa accounts for over one-quarter of newly diagnosed cancers in men and ranks as the second leading cause of cancer-related death; it is estimated that one in twelve men died of cancer is du...

Introduction Prenatal alcohol exposure (PAE) causes neuroinflammation that may contribute to the pathophysiology underlying Fetal Alcohol Spectrum Disorder. Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) has shown success in mitigating effects of PAE animal models, however, mechanisms are unknown. Some PUFA metabolites, specialized pro-resolving mediators (SPMs), play a role r...

The MgO granulated ground blast-furnace slag (GGBS) binder, as a novel has gained increasing attention in recent decades stabilization/solidification (S/S) to treat contaminated soils. In this study, the physical strength and leaching performance of an MgO-GGBS (MG) binder was examined compared with (PC) portland cement PC fly ash (PF) regarding S/S treatment dimethyl phthalates (PAE) soil afte...

The adhesives industry is increasingly interested in products coming from natural and renewable resources. aim of the present work was to improve water resistance soy-based proteins by using synthetic formaldehyde-free additives. These include polyamide-amine epichlorohydrin (PAE), different types isocyanates, combinations these cross-linkers between them with other agents, including metal ions...

Adenosine attenuates the myocardial metabolic and contractile responses induced by ss-adrenergic stimulation. Our study was conducted to investigate the longevity of this antiadrenergic action after adenosine exposure. Adenosine (33 micromol/L) was infused into isolated perfused rat hearts for 1, 5, 30, or 60 minutes, and the adrenergic responsiveness (AR) to isoproterenol (10(-8) mol/L) was de...

CONTEXT Fetal alcohol spectrum disorders (FASD) and prenatal alcohol exposure (PAE) are associated with behavioral difficulties, although there are no published systematic reviews that summarize and critique the literature. OBJECTIVE To describe the behavioral characteristics of children with PAE and/or FASD, assessed using the Achenbach System of Empirically Based Assessments (ASEBA) for sch...

255 Background: Adult survivors of childhood cancer who received radiation therapy have high rates of basal cell carcinoma and melanoma compared with the general population. Both the National Cancer Institute and Children's Oncology Group Guidelines recommend regular skin self-checks and annual clinical skin exams for survivors. The ongoing ASK randomized intervention trial aims to identify str...

Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues upon elastase-based proteolysis of the exposed reactive center loop (RCL). However, the molecular mechanisms that regulate the RCL proteolysis by co-existing host and bacterial elastases in inflamed/infected tissues remain unknown. We document that RCL-localized Asn(347) glycosylation fine-tunes the RC...

PURPOSE To report early results following prostatic artery embolization (PAE) and compare outcomes between nonspherical polyvinyl alcohol (PVA) particles and microspheres to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). METHODS PAE was performed in nine patients (mean age: 78.1 years) with symptomatic BPH. Embolization was performed using nonspherical PV...