RIG-I recognizes molecular patterns in viral RNA to regulate the induction of type I interferons. The C-terminal domain (CTD) of RIG-I exhibits high affinity for 5' triphosphate (ppp) dsRNA as well as blunt-ended dsRNA. Structures of RIG-I CTD bound to 5'-ppp dsRNA showed that RIG-I recognizes the termini of dsRNA and interacts with the ppp through electrostatic interactions. However, the struc...

This paper investigates the purchasing power parity (PPP) hypothesis in Sri Lanka using exchange rates for six currencies during the recent float. Both univariate (Enders and Granger and Ng and Perron unit root tests) and multivariate techniques (asymmetric cointegration and errorcorrection models) are used in the empirical analysis. Enders and Granger unit root tests strongly support the PPP h...

This paper examines the validity of purchasing power parity (PPP) using CPI and Big Mac prices. The benchmark model, i.e., the OLS method, which does not take nonstationarity into account, rejects the hypothesis of PPP regardless of prices used. We next use the panel cointegration method to consider the nonstationary nature of variables. Estimated results for CPI are mixed. The PPP is rejected ...

2. PPPs also bring fiscal risks. These need to be mitigated and managed. To address these challenges, governments usually try to introduce PPP legal and institutional reforms to develop technically sophisticated PPP ecosystems that identify, structure and eventually only pursue PPP proposals that can maximize value-for-money (VfM) to tax-payers. These ecosystems exist to carry transactions from...

Postpartum psychosis (PPP) is a serious mental health issue associated with maternal suicide and infanticide. Although a growing research base suggests that childhood abuse is predictive of psychosis, bipolar disorder, and postpartum depression, the link between abuse and PPP is less clear. Currently, prevention and treatment strategies are pharmacological and require hospitalization once sympt...

Globally, sustainable development has been given high priority for the Government agenda in order to achieve a balance of social, economic and environmental factors. The UK government realise the importance and criticality of sustainable development and they intend to use the public procurement power to demand more sustainable public building development to improve energy efficiency and reduce ...

BACKGROUND Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that PPP treatment induced moderate tolerance in two out of 10 cell lines only, and here report the acquired genomic and expression alterations associated with PPP selection over 1.5 years...

Precise Point Positioning (PPP) has become a very hot topic in GNSS research and applications. However, it usually takes about several tens of minutes in order to obtain positions with better than 10 cm accuracy. This prevents PPP from being widely used in real-time kinematic positioning services, therefore, a large effort has been made to tackle the convergence problem. One of the recent appro...

Several Extensible Authentication Protocol (EAP) [EAP] authentication methods employ X.509 public key certificates. For example, EAP-TLS [EAP-TLS] can be used with PPP [PPP] as well as IEEE 802.1X [802.1X]. PPP is used for dial-up and VPN environments. IEEE 802.1X defines port-based, network access control, and it is used to provide authenticated network access for Ethernet, Token Ring, and Wir...

Several Extensible Authentication Protocol (EAP) [EAP] authentication methods employ X.509 public key certificates. For example, EAP-TLS [EAP-TLS] can be used with PPP [PPP] as well as IEEE 802.1X [802.1X]. PPP is used for dial-up and VPN environments. IEEE 802.1X defines port-based, network access control, and it is used to provide authenticated network access for Ethernet, Token Ring, and Wir...