Glaucoma is a devastating disease that causes damage to the optic nerve and loss of visual function; it is the main cause of blindness in adults. Previous studies have shown that increased intraocular pressure (IOP) is the major risk factor for glaucoma and its progression. 3) With regard to therapy for glaucoma, topical medications are usually chosen as the primary treatment since reducing IOP...

Materials and methods: A total of 159 multiparous sows were assigned in approximately equal numbers to two groups. Group One sows (n = 75) were induced to farrow using two intravulvar injections of 5 mg prostaglandin F2α administered 6 hours apart on day 114 of gestation (Day 0). Farrowing was supervised, with assistance given as required. Group Two sows (n = 84) were allowed to farrow naturall...

We performed a cross-sectional, multicentre study in Japan to detect the differences in biomarkers of exposure and cardiovascular biomarkers between smokers and non-smokers. Several clinically relevant cardiovascular biomarkers differed significantly between smokers and non-smokers, including lipid metabolism (high-density lipoprotein cholesterol concentrations - lower in smokers), inflammation...

Elevated low-density lipoprotein (LDL) concentration in mid-life increases the risk of developing Alzheimer's disease (AD) in later life. Increased oxidized LDL (oxLDL) modification and nitration is observed during dementia and hypercholesterolaemia. We investigated the hypothesis that statin intervention in mid-life mitigates the inflammatory effects of oxLDL on the microvasculature. Human mic...