Heterozygous mutations in GATA2 underlie different syndromes, previously described as monocytopenia and mycobacterial avium complex infection (MonoMAC); dendritic cell, monocytes, B- and NK lymphocytes deficiency (DCML); lymphedema, deafness and myelodysplasia (Emberger syndrome) and familiar myelodysplastic syndrome/acute myeloid leukemia (MDS / AML). Onset and severity of clinical symptoms va...

Background: Clonal hematopoiesis (CH) is frequently incidentally found in liquid biopsy and may reveal a risk situation for developing myeloid malignancy or uncover occult hematologic disease. Material methods: Adult patients with treatment-naïve pre-treated advanced solid cancer enrolled the Gustave Roussy Cancer Profiling study (STING, NCT04932525) underwent at least one next-generation seque...