نتایج جستجو برای: پروتئینα 1a

تعداد نتایج: 31310  

Journal: :Journal of diabetes mellitus 2023

One of the most fundamental molecular processes in response to hypoxia is activation and stabilization a transcriptional factor called induced 1a (HIF-1a), which responsible for regulation many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, metastasis are governed by these This article discusses role hypoxia-inducible (HIF-1a) met...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
M L Beckman E M Bernstein M W Quick

Syntaxin 1A inhibits GABA uptake of an endogenous GABA transporter in neuronal cultures from rat hippocampus and in reconstitution systems expressing the cloned rat brain GABA transporter GAT1. Evidence of interactions between syntaxin 1A and GAT1 comes from three experimental approaches: botulinum toxin cleavage of syntaxin 1A, syntaxin 1A antisense treatments, and coimmunoprecipitation of a c...

Journal: :The Journal of Experimental Medicine 1968
Leon W. Hoyer Tibor Borsos Herbert J. Rapp Wilton E. Vannier

The C'1a-fixing properties of purified rabbit IgM anti-benzenearsonate antibody were determined. When tested with sheep erythrocytes to which hapten had been coupled by diazo linkage, the number of C'1a molecules fixed was 21% of the number of IgM antibody molecules bound to the erythrocyte surface. This was not due to loss of C'1a-fixing capacity during the purification procedure. Preparative ...

Journal: :hepatitis monthly 0
khashayar hesamizadeh baqiyatallah research center for gastroenterology and liver diseases (brcgl), baqiyatallah university of medical sciences, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran seyed moayed alavian baqiyatallah research center for gastroenterology and liver diseases (brcgl), baqiyatallah university of medical sciences, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran azar najafi tireh shabankareh department of medical nanotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, ir iran heidar sharafi baqiyatallah research center for gastroenterology and liver diseases (brcgl), baqiyatallah university of medical sciences, tehran, ir iran; middle east liver diseases (meld) center, tehran, ir iran; baqiyatallah research center for gastroenterology and liver diseases (brcgl), baqiyatallah university of medical sciences, tehran, ir iran. tel: +98-21 8894 5186, fax: +98-2188945188

conclusions in this study, phylogenetic reconstruction of hcv-1 sequences clearly indicated for molecular tracing and ancestral relationships of the hcv genotypes in iran, and showed the likelihood of domestic origin for hcv-1a and various origin for hcv-1b. evidence acquisition the phylogenetic analyses were performed based on the nucleotide sequences of ns5b gene of hcv genotype 1 (hcv-1), wh...

Journal: :iranian journal of basic medical sciences 0
mahshid naghashpour nutrition and metabolic diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, khuzestan, iran department of nutrition, faculty of para-medicine, ahvaz jundishapur university of medical sciences, ahvaz, khuzestan, iran reza amani health research institute, diabetes research center, ahvaz jundishapur university of medical sciences, ahvaz, khuzestan, iran department of nutrition, faculty of para-medicine, ahvaz jundishapur university of medical sciences, ahvaz, khuzestan, iran alireza sarkaki physiology research center, ahvaz jundishapur university of medical sciences, ahvaz, khuzestan, iran department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, khuzestan, iran

objective(s): in the present study, c57bl/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (eae) as a model of multiple sclerosis. materials and methods: the animals were assigned into 7 groups: sham-operated 1 (so1), healthy mice receiving pbs (phosphate buffer saline); sham-operated 2 (so2), he...

Journal: :Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012
Paul R Albert

The serotonin-1A (5-HT(1A)) receptor is an abundant post-synaptic 5-HT receptor (heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the major somatodendritic autoreceptor that negatively regulates 5-HT neuronal activity. Based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-HT(1A) receptors in anxiety and depression phenoty...

2017
Hiroaki Kaku Nichol E. Holodick Joseph R. Tumang Thomas L. Rothstein

B-1a cells are innate-like B-lymphocytes producing natural antibodies. Activation-induced cytidine deaminase (AID), a product of the Aicda gene, plays a central role in class-switch recombination and somatic hypermutation in B cells. Although a role for Aicda in B-1a cells has been suggested on the basis of experiments with knock out (KO) mice, whether B-1a cells express Aicda, and if so, which...

Journal: :iranian journal of microbiology 0
ghasem solgi immunology department, medical school, hamadan university of medical sciences, hamadan, iran. masoud sabouri-ghannad department of microbiology, medical school, hamadan university of medical sciences, hamadan, iran. alireza khalilian department of gastroenterology, medical school, hamadan university of medical sciences, hamadan, iran. amir majlesi department of gastroenterology, medical school, hamadan university of medical sciences, hamadan, iran. mehrdad hajiloo immunology department, medical school, hamadan university of medical sciences, hamadan, iran.

background and objectives : hepatitis c virus genotyping appears to be vital for predicting the response to antiviral therapy. the present study aimed to analyze the hcv genotypes in relation to persistence or clearance of the virus in residents of hamadan province, west-iran. material and methods : a total of 1159 recorded questionnaires of hcv infected people were evaluated in this prospectiv...

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