نتایج جستجو برای: پروتئینα 1a
تعداد نتایج: 31310 فیلتر نتایج به سال:
One of the most fundamental molecular processes in response to hypoxia is activation and stabilization a transcriptional factor called induced 1a (HIF-1a), which responsible for regulation many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, metastasis are governed by these This article discusses role hypoxia-inducible (HIF-1a) met...
Syntaxin 1A inhibits GABA uptake of an endogenous GABA transporter in neuronal cultures from rat hippocampus and in reconstitution systems expressing the cloned rat brain GABA transporter GAT1. Evidence of interactions between syntaxin 1A and GAT1 comes from three experimental approaches: botulinum toxin cleavage of syntaxin 1A, syntaxin 1A antisense treatments, and coimmunoprecipitation of a c...
The C'1a-fixing properties of purified rabbit IgM anti-benzenearsonate antibody were determined. When tested with sheep erythrocytes to which hapten had been coupled by diazo linkage, the number of C'1a molecules fixed was 21% of the number of IgM antibody molecules bound to the erythrocyte surface. This was not due to loss of C'1a-fixing capacity during the purification procedure. Preparative ...
conclusions in this study, phylogenetic reconstruction of hcv-1 sequences clearly indicated for molecular tracing and ancestral relationships of the hcv genotypes in iran, and showed the likelihood of domestic origin for hcv-1a and various origin for hcv-1b. evidence acquisition the phylogenetic analyses were performed based on the nucleotide sequences of ns5b gene of hcv genotype 1 (hcv-1), wh...
objective(s): in the present study, c57bl/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (eae) as a model of multiple sclerosis. materials and methods: the animals were assigned into 7 groups: sham-operated 1 (so1), healthy mice receiving pbs (phosphate buffer saline); sham-operated 2 (so2), he...
The serotonin-1A (5-HT(1A)) receptor is an abundant post-synaptic 5-HT receptor (heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the major somatodendritic autoreceptor that negatively regulates 5-HT neuronal activity. Based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-HT(1A) receptors in anxiety and depression phenoty...
B-1a cells are innate-like B-lymphocytes producing natural antibodies. Activation-induced cytidine deaminase (AID), a product of the Aicda gene, plays a central role in class-switch recombination and somatic hypermutation in B cells. Although a role for Aicda in B-1a cells has been suggested on the basis of experiments with knock out (KO) mice, whether B-1a cells express Aicda, and if so, which...
background and objectives : hepatitis c virus genotyping appears to be vital for predicting the response to antiviral therapy. the present study aimed to analyze the hcv genotypes in relation to persistence or clearance of the virus in residents of hamadan province, west-iran. material and methods : a total of 1159 recorded questionnaires of hcv infected people were evaluated in this prospectiv...
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